| Tag | Content |
|---|
| CPLM ID | CPLM-018778 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Minor histocompatibility protein HA-1 |
Protein Synonyms/Alias | Minor histocompatibility antigen HA-1; mHag HA-1 |
Gene Name | HMHA1 |
Gene Synonyms/Alias | KIAA0223 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 305 | DLISYLEKRTTLEME | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | GTPase activator for the Rho-type GTPases (Potential). |
Sequence Annotation | DOMAIN 761 974 Rho-GAP.
ZN_FING 702 747 Phorbol-ester/DAG-type.
MOD_RES 23 23 Phosphoserine.
MOD_RES 25 25 Phosphoserine.
MOD_RES 73 73 Phosphoserine.
MOD_RES 93 93 Phosphoserine.
MOD_RES 99 99 Phosphoserine.
MOD_RES 569 569 Phosphoserine.
MOD_RES 578 578 Phosphoserine (By similarity).
MOD_RES 619 619 Phosphoserine.
MOD_RES 1027 1027 Phosphoserine (By similarity).
MOD_RES 1030 1030 Phosphoserine (By similarity).
MOD_RES 1032 1032 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; GTPase activation; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1136 AA |
Protein Sequence | MFSRKKRELM KTPSISKKNR AGSPSPQPSG ELPRKDGADA VFPGPSLEPP AGSSGVKATG 60
TLKRPTSLSR HASAAGFPLS GAASWTLGRS HRSPLTAASP GELPTEGAGP DVVEDISHLL 120
ADVARFAEGL EKLKECVLRD DLLEARRPRA HECLGEALRV MHQIISKYPL LNTVETLTAA 180
GTLIAKVKAF HYESNNDLEK QEFEKALETI AVAFSSTVSE FLMGEVDSST LLAVPPGDSS 240
QSMESLYGPG SEGTPPSLED CDAGCLPAEE VDVLLQRCEG GVDAALLYAK NMAKYMKDLI 300
SYLEKRTTLE MEFAKGLQKI AHNCRQSVMQ EPHMPLLSIY SLALEQDLEF GHSMVQAVGT 360
LQTQTFMQPL TLRRLEHEKR RKEIKEAWHR AQRKLQEAES NLRKAKQGYV QRCEDHDKAR 420
FLVAKAEEEQ AGSAPGAGST ATKTLDKRRR LEEEAKNKAE EAMATYRTCV ADAKTQKQEL 480
EDTKVTALRQ IQEVIRQSDQ TIKSATISYY QMMHMQTAPL PVHFQMLCES SKLYDPGQQY 540
ASHVRQLQRD QEPDVHYDFE PHVSANAWSP VMRARKSSFN VSDVARPEAA GSPPEEGGCT 600
EGTPAKDHRA GRGHQVHKSW PLSISDSDSG LDPGPGAGDF KKFERTSSSG TMSSTEELVD 660
PDGGAGASAF EQADLNGMTP ELPVAVPSGP FRHEGLSKAA RTHRLRKLRT PAKCRECNSY 720
VYFQGAECEE CCLACHKKCL ETLAIQCGHK KLQGRLQLFG QDFSHAARSA PDGVPFIVKK 780
CVCEIERRAL RTKGIYRVNG VKTRVEKLCQ AFENGKELVE LSQASPHDIS NVLKLYLRQL 840
PEPLISFRLY HELVGLAKDS LKAEAEAKAA SRGRQDGSES EAVAVALAGR LRELLRDLPP 900
ENRASLQYLL RHLRRIVEVE QDNKMTPGNL GIVFGPTLLR PRPTEATVSL SSLVDYPHQA 960
RVIETLIVHY GLVFEEEPEE TPGGQDESSN QRAEVVVQVP YLEAGEAVVY PLQEAAADGC 1020
RESRVVSNDS DSDLEEASEL LSSSEASALG HLSFLEQQQS EASLEVASGS HSGSEEQLEA 1080
TAREDGDGDE DGPAQQLSGF NTNQSNNVLQ APLPPMRLRG GRMTLGSCRE RQPEFV 1136 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |