CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003788
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 
Protein Synonyms/Alias
 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 
Gene Name
 hisA 
Gene Synonyms/Alias
 b2024; JW2006 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
23LHQGDYGKQRDYGNDacetylation[1]
55LVDLTGAKDPAKRQIacetylation[1]
66KRQIPLIKTLVAGVNacetylation[1]
107VVGSTAVKSQDMVKGacetylation[1]
113VKSQDMVKGWFERFGacetylation[1]
232GRALLEGKFTVKEAIacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 ACT_SITE 7 7 Proton acceptor (By similarity).
 ACT_SITE 129 129 Proton donor (By similarity).  
Keyword
 Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 245 AA 
Protein Sequence
MIIPALDLID GTVVRLHQGD YGKQRDYGND PLPRLQDYAA QGAEVLHLVD LTGAKDPAKR 60
QIPLIKTLVA GVNVPVQVGG GVRSEEDVAA LLEAGVARVV VGSTAVKSQD MVKGWFERFG 120
ADALVLALDV RIDEQGNKQV AVSGWQENSG VSLEQLVETY LPVGLKHVLC TDISRDGTLA 180
GSNVSLYEEV CARYPQVAFQ SSGGIGDIDD VAALRGTGVR GVIVGRALLE GKFTVKEAIA 240
CWQNA 245 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IDA:EcoCyc.
 GO:0000105; P:histidine biosynthetic process; IDA:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR006062; His_biosynth.
 IPR006063; HisA.
 IPR023016; Isoase_HisA.
 IPR011060; RibuloseP-bd_barrel. 
Pfam
 PF00977; His_biosynth 
SMART
  
PROSITE
  
PRINTS