UniProt Accession

 PPP5_RAT; P53042 

Genbank Protein ID

 X77237 

Genbank Nucleotide ID

 CAA54454.1 

Protein Name

 Serine/threonine-protein phosphatase 5 

Protein Synonyms/Alias

 PP5; Protein phosphatase T; PPT 

Gene Name

 Ppp5c 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
40	TQANDYFKAKDYENA	acetylation	[1]
93	TRAIELDKKYIKGYY	acetylation	[1]
94	RAIELDKKYIKGYYR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May play a role in the regulation of RNA biogenesis and/or mitosis. 

Sequence Annotation

 REPEAT 28 61 TPR 1.
 REPEAT 62 95 TPR 2.
 REPEAT 96 129 TPR 3.
 REGION 200 499 Catalytic.
 ACT_SITE 304 304 Proton donor (By similarity).
 METAL 242 242 Iron (By similarity).
 METAL 244 244 Iron (By similarity).
 METAL 271 271 Iron (By similarity).
 METAL 271 271 Manganese (By similarity).
 METAL 303 303 Manganese (By similarity).
 METAL 352 352 Manganese (By similarity).
 METAL 427 427 Manganese (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 499 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IPI:RGD.
 GO:0043278; P:response to morphine; IEA:Compara. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR013235; PPP_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase.
 IPR011236; Ser/Thr_PPase_5.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00149; Metallophos
 PF08321; PPP5
 PF00515; TPR_1 

SMART

 SM00156; PP2Ac
 SM00028; TPR 

PROSITE

 PS00125; SER_THR_PHOSPHATASE
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS

 PR00114; STPHPHTASE.