| Tag | Content |
|---|
| CPLM ID | CPLM-006748 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit DhaM |
Protein Synonyms/Alias | Phosphocarrier protein HPr; Protein H; Phosphotransferase enzyme IIA component; PTS system EIIA component |
Gene Name | dhaM |
Gene Synonyms/Alias | ycgC; b1198; JW5185 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 464 | ETLTLDVKTQRFNRQ | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Phosphotransferase subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaM serves as the phosphoryl donor. It is phosphorylated by HPr, then it donates its phosphoryl group to DhaL-ADP, which eventually transmits it to dihydroxyacetone. |
Sequence Annotation | DOMAIN 1 135 PTS EIIA type-4.
DOMAIN 155 242 HPr.
REGION 264 472 PTS EI.
ACT_SITE 9 9 Tele-phosphohistidine intermediate; for
ACT_SITE 169 169 Pros-phosphohistidine intermediate; for
ACT_SITE 430 430 Tele-phosphohistidine intermediate |
Keyword | ATP-binding; Complete proteome; Glycerol metabolism; Kinase; Nucleotide-binding; Phosphotransferase system; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 472 AA |
Protein Sequence | MVNLVIVSHS SRLGEGVGEL ARQMLMSDSC KIAIAAGIDD PQNPIGTDAV KVMEAIESVA 60
DADHVLVMMD MGSALLSAET ALELLAPEIA AKVRLCAAPL VEGTLAATVS AASGADIDKV 120
IFDAMHALEA KREQLGLPSS DTEISDTCPA YDEEARSLAV VIKNRNGLHV RPASRLVYTL 180
STFNADMLLE KNGKCVTPES INQIALLQVR YNDTLRLIAK GPEAEEALIA FRQLAEDNFG 240
ETEEVAPPTL RPVPPVSGKA FYYQPVLCTV QAKSTLTVEE EQDRLRQAID FTLLDLMTLT 300
AKAEASGLDD IAAIFSGHHT LLDDPELLAA ASELLQHEHC TAEYAWQQVL KELSQQYQQL 360
DDEYLQARYI DVDDLLHRTL VHLTQTKEEL PQFNSPTILL AENIYPSTVL QLDPAVVKGI 420
CLSAGSPVSH SALIARELGI GWICQQGEKL YAIQPEETLT LDVKTQRFNR QG 472 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0016021; C:integral to membrane; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016301; F:kinase activity; IEA:UniProtKB-KW. GO:0008965; F:phosphoenolpyruvate-protein phosphotransferase activity; IDA:EcoCyc. GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro. GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway. GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |