| Tag | Content |
|---|
| CPLM ID | CPLM-019790 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitogen-activated protein kinase kinase kinase 3 |
Protein Synonyms/Alias | MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3 |
Gene Name | MAP3K3 |
Gene Synonyms/Alias | MAPKKK3; MEKK3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 397 | PINWRRGKLLGQGAF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. |
Sequence Annotation | DOMAIN 44 123 OPR.
DOMAIN 362 622 Protein kinase.
NP_BIND 368 376 ATP (By similarity).
ACT_SITE 489 489 Proton acceptor (By similarity).
BINDING 391 391 ATP (By similarity).
MOD_RES 166 166 Phosphoserine; by SGK1.
MOD_RES 250 250 Phosphoserine.
MOD_RES 337 337 Phosphoserine; by SGK1.
MOD_RES 340 340 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 626 AA |
Protein Sequence | MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQKKHNSSSS ALLNSPTVTT 60
SSCAGASEKK KFLSDVRIKF EHNGERRIIA FSRPVKYEDV EHKVTTVFGQ PLDLHYMNNE 120
LSILLKNQDD LDKAIDILDR SSSMKSLRIL LLSQDRNHNS SSPHSGVSRQ VRIKASQSAG 180
DINTIYQPPE PRSRHLSVSS QNPGRSSPPP GYVPERQQHI ARQGSYTSIN SEGEFIPETS 240
EQCMLDPLSS AENSLSGSCQ SLDRSADSPS FRKSRMSRAQ SFPDNRQEYS DRETQLYDKG 300
VKGGTYPRRY HVSVHHKDYS DGRRTFPRIR RHQGNLFTLV PSSRSLSTNG ENMGLAVQYL 360
DPRGRLRSAD SENALSVQER NVPTKSPSAP INWRRGKLLG QGAFGRVYLC YDVDTGRELA 420
SKQVQFDPDS PETSKEVSAL ECEIQLLKNL QHERIVQYYG CLRDRAEKTL TIFMEYMPGG 480
SVKDQLKAYG ALTESVTRKY TRQILEGMSY LHSNMIVHRD IKGANILRDS AGNVKLGDFG 540
ASKRLQTICM SGTGMRSVTG TPYWMSPEVI SGEGYGRKAD VWSLGCTVVE MLTEKPPWAE 600
YEAMAAIFKI ATQPTNPQLP SHISEHGRDF LRRIFVEARQ RPSAEELLTH HFAQLMY 657 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004709; F:MAP kinase kinase kinase activity; TAS:ProtInc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB. GO:0046777; P:protein autophosphorylation; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |