| Tag | Content |
|---|
| CPLM ID | CPLM-014625 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Protein Synonyms/Alias | 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24 |
Gene Name | Cyp24a1 |
Gene Synonyms/Alias | Cyp-24; Cyp24 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 378 | VRNMPYLKACLKESM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. |
Sequence Annotation | METAL 462 462 Iron (heme axial ligand) (Potential). |
Keyword | Complete proteome; Heme; Iron; Metal-binding; Mitochondrion; Monooxygenase; NADP; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 514 AA |
Protein Sequence | MSCPIDKRRP LIAFLRRLRD LGQPPRSVTS KAHVKRAPKE VPLCPLMTDG ETRNVTSLPG 60
PTNWPLLGSL LEIFWKGGLK KQHDTLAEYH KKYGQIFRMK LGSFDSVHLG SPSLLEALYR 120
TESAHPQRLE IKPWKAYRDH RNEAYGLMIL EGQEWQRVRS AFQKKLMKPV EIMKLDKKIN 180
EVLADFMGQI DELRDERGRI QDLYSELNKW SFESICLVLY EKRFGLLQKD TEEEALTFIA 240
AIKTMMSTFG KMMVTPVELH KRLNTKVWQA HTLAWDTIFK SVKPCIDHRL ERYSQQPGAD 300
FLCDIYQQDH LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ RLLREIQSVL 360
PDNQTPRAED VRNMPYLKAC LKESMRLTPS VPFTTRTLDK PTVLGEYTLP KGTVLTLNTQ 420
VLGSSEDNFE DADKFRPERW LEKEKKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWII 480
QKYNIVATDS EPVEMLHLGI LVPSRELPIA FCPR 514 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:MGI. GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IEA:Compara. GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IMP:MGI. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0001649; P:osteoblast differentiation; IEA:Compara. GO:0033280; P:response to vitamin D; IEA:Compara. GO:0042359; P:vitamin D metabolic process; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |