UniProt Accession

 CD2_HUMAN; P06729; Q96TE5 

Genbank Protein ID

 M19806; M19798; M19800; M19802; M19804; M16445; M14362; M16336; X07871; X07872; X07873; X07874; AL135798; BC033583 

Genbank Nucleotide ID

 AAA53095.1; AAA53095.1; AAA53095.1; AAA53095.1; AAA53095.1; AAA51738.1; AAA35571.1; AAA51946.1; CAA30721.1; CAA30721.1; CAA30721.1; CAA30721.1; CAC14840.1; AAH33583.1 

Protein Name

 T-cell surface antigen CD2 

Protein Synonyms/Alias

 Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD2 

Gene Name

 CD2 

Gene Synonyms/Alias

 SRBC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
125	LEKIFDLKIQERVSK	ubiquitination	[1]
194	TAGNKVSKESSVEPV	ubiquitination	[2]
206	EPVSCPEKGLDIYLI	ubiquitination	[2]
264	ATEERGRKPHQIPAS	ubiquitination	[3]
310	RVQHQPQKRPPAPSG	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. 

Sequence Annotation

 DOMAIN 25 128 Ig-like V-type.
 DOMAIN 129 209 Ig-like C2-type.
 REGION 61 75 LFA-3 (CD58) binding region 1.
 REGION 106 120 LFA-3 (CD58) binding region 2.
 CARBOHYD 89 89 N-linked (GlcNAc...).
 CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 DISULFID 139 203
 DISULFID 146 186  

Keyword

 3D-structure; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 351 AA 

Protein Sequence

Gene Ontology

 GO:0046658; C:anchored to plasma membrane; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005576; C:extracellular region; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0004872; F:receptor activity; NAS:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:UniProtKB.
 GO:0016337; P:cell-cell adhesion; NAS:UniProtKB.
 GO:0006917; P:induction of apoptosis; TAS:UniProtKB.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0001766; P:membrane raft polarization; TAS:UniProtKB.
 GO:0030101; P:natural killer cell activation; NAS:UniProtKB.
 GO:0030887; P:positive regulation of myeloid dendritic cell activation; NAS:UniProtKB.
 GO:0045580; P:regulation of T cell differentiation; NAS:UniProtKB.
 GO:0042110; P:T cell activation; TAS:UniProtKB. 

Interpro

 IPR013783; Ig-like_fold.
 IPR008424; Ig_C2-set.
 IPR013106; Ig_V-set.
 IPR015631; SLAM_fam_rcpts.
 IPR015632; T-cell_sdhesion_molc_CD2. 

Pfam

 PF05790; C2-set
 PF07686; V-set 

SMART

  

PROSITE

 PS50835; IG_LIKE 

PRINTS

 PR01870; CD2ANTIGEN.