CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein Musashi homolog 2 
Protein Synonyms/Alias
 Musashi-2 
Gene Name
 MSI2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
141DAMLMFDKTTNRHRGubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). 
Sequence Annotation
 DOMAIN 21 111 RRM 1.
 DOMAIN 110 187 RRM 2.
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MADLTSVLTS VMFSPSSKMF IGGLSWQTSP DSLRDYFSKF GEIRECMVMR DPTTKRSRGF 60
GFVTFADPAS VDKVLGQPHH ELDSKTIDPK VAFPRRAQPK MVTRTKKIFV GGLSANTVVE 120
DVKQYFEQFG KVEDAMLMFD KTTNRHRGFG FVTFENEDVV EKVCEIHFHE INNKMVECKK 180
AQPKEVMFPP GTRGRARGLP YTMDAFMLGM GMLGYPNFVA TYGRGYPGFA PSYGYQFPDY 240
LPVSQDIIFI N 251 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005844; C:polysome; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008266; F:poly(U) RNA binding; IEA:Compara.
 GO:0048864; P:stem cell development; IEA:Compara. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS