| Tag | Content |
|---|
| CPLM ID | CPLM-016830 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 22 member 12 |
Protein Synonyms/Alias | Renal-specific transporter; RST; Urate anion exchanger 1 |
Gene Name | Slc22a12 |
Gene Synonyms/Alias | Urat1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 291 | RWLITVGKLDQGLQE | ubiquitination | [1] | | 309 | VAAVNRRKAEGDTLT | ubiquitination | [1] | | 332 | EEEPSRDKAGASLGT | ubiquitination | [1] | | 532 | DTIQDIQKQSVKKVT | ubiquitination | [1] | | 537 | IQKQSVKKVTHDTPD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions. |
Sequence Annotation | CARBOHYD 56 56 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MAFPELLDRV GGLGRFQLFQ TVALVTPILW VTTQNMLENF SAAVPHHRCW VPLLDNSTSQ 60
ASIPGDLGPD VLLAVSIPPG PDQQPHQCLR FRQPQWQLTE SNATATNWSD AATEPCEDGW 120
VYDHSTFRST IVTTWDLVCN SQALRPMAQS IFLAGILVGA AVCGHASDRF GRRRVLTWSY 180
LLVSVSGTAA AFMPTFPLYC LFRFLLASAV AGVMMNTASL LMEWTSAQGS PLVMTLNALG 240
FSFGQVLTGS VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG KLDQGLQELQ 300
RVAAVNRRKA EGDTLTMEVL RSAMEEEPSR DKAGASLGTL LHTPGLRHRT IISMLCWFAF 360
GFTFYGLALD LQALGSNIFL LQALIGIVDF PVKTGSLLLI SRLGRRFCQV SFLVLPGLCI 420
LSNILVPHGM GVLRSALAVL GLGCLGGAFT CITIFSSELF PTVIRMTAVG LCQVAARGGA 480
MLGPLVRLLG VYGSWMPLLV YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH 540
DTPDGSILMS TRL 553 |
Gene Ontology | GO:0016324; C:apical plasma membrane; ISS:UniProtKB. GO:0031526; C:brush border membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; IDA:UniProtKB. GO:0030165; F:PDZ domain binding; ISS:UniProtKB. GO:0015143; F:urate transmembrane transporter activity; IDA:UniProtKB. GO:0042493; P:response to drug; ISS:UniProtKB. GO:0046415; P:urate metabolic process; IEA:Compara. GO:0015747; P:urate transport; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |