CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008113
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin beta-1 
Protein Synonyms/Alias
 Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD29 
Gene Name
 Itgb1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
122QPQQLLLKLRSGEPQacetylation[1]
130LRSGEPQKFTLKFKRacetylation[1]
349QPVYKELKNLIPKSAacetylation[1]
795VTTVVNPKYEGK***acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation (By similarity). Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). 
Sequence Annotation
 DOMAIN 140 378 VWFA.
 REPEAT 467 516 I.
 REPEAT 517 560 II.
 REPEAT 561 599 III.
 REPEAT 600 636 IV.
 REGION 467 636 Cysteine-rich tandem repeats.
 REGION 786 793 Interaction with ITGB1BP1 (By
 METAL 152 152 Magnesium (By similarity).
 METAL 154 154 Calcium 1; via carbonyl oxygen (By
 METAL 156 156 Calcium 1 (By similarity).
 METAL 157 157 Calcium 1 (By similarity).
 METAL 189 189 Calcium 2 (By similarity).
 METAL 244 244 Calcium 2 (By similarity).
 METAL 246 246 Calcium 2 (By similarity).
 METAL 248 248 Calcium 2; via carbonyl oxygen (By
 METAL 249 249 Calcium 2 (By similarity).
 METAL 249 249 Magnesium (By similarity).
 MOD_RES 186 186 Phosphoserine (By similarity).
 MOD_RES 778 778 Phosphothreonine (By similarity).
 MOD_RES 784 784 Phosphotyrosine (By similarity).
 MOD_RES 795 795 N6-acetyllysine (By similarity).
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
 CARBOHYD 363 363 N-linked (GlcNAc...) (Potential).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 417 417 N-linked (GlcNAc...) (Potential).
 CARBOHYD 482 482 N-linked (GlcNAc...) (Potential).
 CARBOHYD 521 521 N-linked (GlcNAc...) (Potential).
 CARBOHYD 585 585 N-linked (GlcNAc...) (Potential).
 CARBOHYD 670 670 N-linked (GlcNAc...) (Potential).
 DISULFID 27 45 By similarity.
 DISULFID 35 465 By similarity.
 DISULFID 38 75 By similarity.
 DISULFID 48 64 By similarity.
 DISULFID 207 213 By similarity.
 DISULFID 261 301 By similarity.
 DISULFID 401 415 By similarity.
 DISULFID 435 463 By similarity.
 DISULFID 467 692 By similarity.
 DISULFID 478 490 By similarity.
 DISULFID 487 526 By similarity.
 DISULFID 492 501 By similarity.
 DISULFID 503 517 By similarity.
 DISULFID 532 537 By similarity.
 DISULFID 534 569 By similarity.
 DISULFID 539 554 By similarity.
 DISULFID 556 561 By similarity.
 DISULFID 575 580 By similarity.
 DISULFID 577 608 By similarity.
 DISULFID 582 591 By similarity.
 DISULFID 593 600 By similarity.
 DISULFID 614 619 By similarity.
 DISULFID 616 662 By similarity.
 DISULFID 621 631 By similarity.
 DISULFID 634 637 By similarity.
 DISULFID 641 650 By similarity.
 DISULFID 647 724 By similarity.
 DISULFID 666 700 By similarity.  
Keyword
 Acetylation; Cell adhesion; Cell membrane; Cell projection; Complete proteome; Disulfide bond; Glycoprotein; Integrin; Magnesium; Membrane; Metal-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 799 AA 
Protein Sequence
MNLQLVFWIG LISLICSVFG QTDKNRCLKA NAKSCGECIQ AGPNCGWCTN TTFLQEGMPT 60
SARCDDLEAL KKKGCHPSDI ENPRGSQTIK KNKNVTNRSK GMAEKLRPED ITQIQPQQLL 120
LKLRSGEPQK FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180
RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTDRGE FFNELVGQQR 240
ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300
CHLENNVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360
SGNSSNVIQL IIDAYNSLSS EVILENSKLP DGVTINYKSY CKNGVNGTGE NGRKCSNISI 420
GDEVQFEISI TANKCPNKES ENQLKLNPLG FTEEVEVVLQ FICKCNCQSH GIPASPKCHE 480
GNGTFECGAC RCNEGRVGRH CECSTDEVNS EDMDAYCRKE NSSEICSNNG ECVCGQCVCR 540
KRENTNEIYS GKFCECDNFN CDRSNGLICG GNGVCRCRVC ECYPNYTGSA CDCSLDTVPC 600
VATNGQICNG RGICECGACK CTDPKFQGPT CETCQTCLGV CAEHKECVQC RAFNKGEKKD 660
TCAQECSHFN LTKVESREKL PQPVQVDPVT HCKEKDIDDC WFYFTYSVNS KGEAHVHVVE 720
TPDCPTGPDI IPIVAGVVAG IVLIGLALLL IWKLLMIIHD RREFAKFEKE KMNAKWDTGE 780
NPIYKSAVTT VVNPKYEGK 799 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:RGD.
 GO:0034667; C:alpha3-beta1 integrin complex; IDA:RGD.
 GO:0034679; C:alpha9-beta1 integrin complex; IDA:RGD.
 GO:0005604; C:basement membrane; IDA:RGD.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005911; C:cell-cell junction; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0005925; C:focal adhesion; IDA:RGD.
 GO:0030056; C:hemidesmosome; IDA:RGD.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0051393; F:alpha-actinin binding; IDA:RGD.
 GO:0005518; F:collagen binding; IDA:RGD.
 GO:0001968; F:fibronectin binding; IDA:RGD.
 GO:0005178; F:integrin binding; IMP:RGD.
 GO:0043236; F:laminin binding; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042277; F:peptide binding; IDA:RGD.
 GO:0019904; F:protein domain specific binding; IDA:RGD.
 GO:0046982; F:protein heterodimerization activity; IMP:RGD.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007161; P:calcium-independent cell-matrix adhesion; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0007155; P:cell adhesion; IDA:RGD.
 GO:0001708; P:cell fate specification; IEA:Compara.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:0033631; P:cell-cell adhesion mediated by integrin; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IDA:RGD.
 GO:0071479; P:cellular response to ionizing radiation; IEP:RGD.
 GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
 GO:0071305; P:cellular response to vitamin D; IEP:RGD.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0008354; P:germ cell migration; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IDA:RGD.
 GO:0007159; P:leukocyte cell-cell adhesion; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
 GO:2000811; P:negative regulation of anoikis; IEA:Compara.
 GO:0031345; P:negative regulation of cell projection organization; IMP:RGD.
 GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.
 GO:0045665; P:negative regulation of neuron differentiation; IMP:RGD.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IMP:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:RGD.
 GO:0045807; P:positive regulation of endocytosis; IMP:RGD.
 GO:0043410; P:positive regulation of MAPK cascade; IDA:RGD.
 GO:0045666; P:positive regulation of neuron differentiation; IMP:RGD.
 GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:RGD.
 GO:0032594; P:protein transport within lipid bilayer; IMP:RGD.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IMP:RGD.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0034698; P:response to gonadotropin stimulus; IEP:RGD.
 GO:0071559; P:response to transforming growth factor beta stimulus; IEP:RGD.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0070830; P:tight junction assembly; IMP:RGD.
 GO:0001894; P:tissue homeostasis; IMP:RGD. 
Interpro
 IPR013111; EGF_extracell.
 IPR027071; Integrin_beta-1.
 IPR015812; Integrin_bsu.
 IPR014836; Integrin_bsu_cyt_dom.
 IPR002369; Integrin_bsu_N.
 IPR012896; Integrin_bsu_tail.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002035; VWF_A. 
Pfam
 PF07974; EGF_2
 PF08725; Integrin_b_cyt
 PF07965; Integrin_B_tail
 PF00362; Integrin_beta 
SMART
 SM00187; INB
 SM00423; PSI
 SM00327; VWA 
PROSITE
 PS00022; EGF_1
 PS00243; INTEGRIN_BETA
 PS50234; VWFA 
PRINTS
 PR01186; INTEGRINB.