CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018247
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycine N-acyltransferase-like protein 2 
Protein Synonyms/Alias
 Acyl-CoA:glycine N-acyltransferase-like protein 2 
Gene Name
 GLYATL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15QKLQILYKSLEKSIPacetylation[1]
19ILYKSLEKSIPESIKacetylation[1]
26KSIPESIKVYGAIFNacetylation[1]
Reference
 [1] Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules.
 Waluk DP, Sucharski F, Sipos L, Silberring J, Hunt MC.
 J Biol Chem. 2012 May 11;287(20):16158-67. [PMID: 22408254] 
Functional Description
 Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0- CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine. 
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Endoplasmic reticulum; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 294 AA 
Protein Sequence
MLVLHNSQKL QILYKSLEKS IPESIKVYGA IFNIKDKNPF NMEVLVDAWP DYQIVITRPQ 60
KQEMKDDQDH YTNTYHIFTK APDKLEEVLS YSNVISWEQT LQIQGCQEGL DEAIRKVATS 120
KSVQVDYMKT ILFIPELPKK HKTSSNDKME LFEVDDDNKE GNFSNMFLDA SHAGLVNEHW 180
AFGKNERSLK YIERCLQDFL GFGVLGPEGQ LVSWIVMEQS CELRMGYTVP KYRHQGNMLQ 240
IGYHLEKYLS QKEIPFYFHV ADNNEKSLQA LNNLGFKICP CGWHQWKCTP KKYC 294 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:InterPro.
 GO:0047961; F:glycine N-acyltransferase activity; IEA:EC. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR010313; Glycine_N-acyltransferase.
 IPR013652; Glycine_N-acyltransferase_C.
 IPR015938; Glycine_N-acyltransferase_N. 
Pfam
 PF08444; Gly_acyl_tr_C
 PF06021; Gly_acyl_tr_N 
SMART
  
PROSITE
  
PRINTS