UniProt Accession

 K7EKB6_HUMAN; K7EKB6 

Genbank Protein ID

 AC006538 

Genbank Nucleotide ID

  

Protein Name

 Thimet oligopeptidase 

Protein Synonyms/Alias

  

Gene Name

 THOP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	RELIEQTKRVYDQVG	ubiquitination	[1]
82	PQHVSPSKDIRTAST	ubiquitination	[2, 3]
93	TASTEADKKLSEFDV	ubiquitination	[2]
94	ASTEADKKLSEFDVE	ubiquitination	[2]
118	RIVWLQEKVQKDSLR	ubiquitination	[2]
121	WLQEKVQKDSLRPEA	ubiquitination	[2]
160	NIKRIKKKLSLLCID	ubiquitination	[2]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0004222; F:metalloendopeptidase activity; IEA:Compara.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0007243; P:intracellular protein kinase cascade; IEA:Compara.
 GO:0006518; P:peptide metabolic process; IEA:Compara. 

Interpro

 IPR024080; Neurolysin/TOP_N. 

Pfam

  

SMART

  

PROSITE

  

PRINTS