UniProt Accession

 SMRC2_MOUSE; Q6PDG5; Q6P6P3 

Genbank Protein ID

 BC058720; BC062102 

Genbank Nucleotide ID

 AAH58720.1; AAH62102.1 

Protein Name

 SWI/SNF complex subunit SMARCC2 

Protein Synonyms/Alias

 BRG1-associated factor 170; BAF170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 

Gene Name

 Smarcc2 

Gene Synonyms/Alias

 Baf170 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
33	NVRLWLGKNYKKYIQ	ubiquitination	[1]
568	FPEKGKEKPADMQNF	ubiquitination	[1]
694	RVASAAAKSALEEFS	ubiquitination	[1]
704	LEEFSKMKEEVPTAL	ubiquitination	[1]
825	IVDPEKDKEPTEGQE	ubiquitination	[1]
872	ALAAAAVKAKHLAAV	ubiquitination	[1]
874	AAAAVKAKHLAAVEE	ubiquitination	[1]
940	AFHMEQLKYAEMRAR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 

Sequence Annotation

 DOMAIN 424 521 SWIRM.
 DOMAIN 596 647 SANT.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 286 286 Phosphoserine (By similarity).
 MOD_RES 302 302 Phosphoserine.
 MOD_RES 304 304 Phosphoserine.
 MOD_RES 306 306 Phosphoserine (By similarity).
 MOD_RES 326 326 N6-acetyllysine (By similarity).
 MOD_RES 347 347 Phosphoserine.
 MOD_RES 806 806 Phosphoserine.
 MOD_RES 810 810 Phosphoserine.
 MOD_RES 813 813 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1213 AA 

Protein Sequence

Gene Ontology

 GO:0071565; C:nBAF complex; IDA:UniProtKB.
 GO:0071564; C:npBAF complex; IDA:UniProtKB.
 GO:0016514; C:SWI/SNF complex; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006338; P:chromatin remodeling; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0006337; P:nucleosome disassembly; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001357; BRCT_dom.
 IPR000953; Chromo_domain/shadow.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR007526; SWIRM.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00249; Myb_DNA-binding
 PF04433; SWIRM 

SMART

 SM00298; CHROMO
 SM00717; SANT 

PROSITE

 PS51293; SANT
 PS50934; SWIRM 

PRINTS