UniProt Accession

 F6SAC3_MOUSE; F6SAC3 

Genbank Protein ID

 AC132451 

Genbank Nucleotide ID

  

Protein Name

 Glucose-6-phosphate isomerase 

Protein Synonyms/Alias

  

Gene Name

 Gm1840 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	YSKNLVNKEVMQMLV	acetylation	[1, 2]
67	QMLVELAKSRGVEAA	ubiquitination	[3]
151	EWFLEAAKDPSAVAK	acetylation	[2, 4]
151	EWFLEAAKDPSAVAK	succinylation	[4]
158	KDPSAVAKHFVALST	acetylation	[2]
158	KDPSAVAKHFVALST	ubiquitination	[3]
169	ALSTNTAKVKEFGID	ubiquitination	[3]
279	GDMESNGKYITKSGA	ubiquitination	[3]
364	KLPEEARKELQAAGK	ubiquitination	[3]
371	KELQAAGKSPEDLEK	acetylation	[1, 4]
371	KELQAAGKSPEDLEK	succinylation	[4]
378	KSPEDLEKLLPHKVF	acetylation	[4]
383	LEKLLPHKVFEGNRP	ubiquitination	[3]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Gluconeogenesis; Glycolysis; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 471 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:EC.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001672; G6P_Isomerase.
 IPR023096; G6P_Isomerase_C.
 IPR018189; Phosphoglucose_isomerase_CS. 

Pfam

 PF00342; PGI 

SMART

  

PROSITE

 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 

PRINTS

 PR00662; G6PISOMERASE.