| Tag | Content |
|---|
| CPLM ID | CPLM-013153 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inactive phospholipase C-like protein 1 |
Protein Synonyms/Alias | PLC-L1; Phospholipase C-related but catalytically inactive protein; PRIP |
Gene Name | Plcl1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 533 | SYLPSPEKLKNMIIV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as a inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors. |
Sequence Annotation | DOMAIN 114 224 PH.
DOMAIN 399 543 PI-PLC X-box.
DOMAIN 586 702 PI-PLC Y-box.
DOMAIN 709 814 C2.
REGION 83 222 Interaction with PPP1C (By similarity).
REGION 544 568 Interaction with GABA A beta subunit (By
MOD_RES 94 94 Phosphothreonine; by PKA.
MOD_RES 96 96 Phosphoserine; by PKA.
MOD_RES 557 557 Phosphothreonine. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1096 AA |
Protein Sequence | MAEGAASREA PAPLDVAGGE DDPRAGADAA SGDAPPPALG GRMRDRRSGV ALPGAAGVPA 60
DSEAGLLEAA RATPRRSSII KDPSNQKCGG RKKTVSFSSM PSEKKISSAH DCISFMQAGC 120
ELKKVRPNSR IYNRFFTLDT DLQALRWEPS KKDLEKAKLD ISAIKEIRLG KNTETFRNNG 180
LADQICEDCA FSILHGENYE SLDLVANSAD VANIWVSGLR YLVSRSKQPL DFIEGNQNTP 240
RFMWLKTVFE AADVDGNGIM LEDTSVELIK QLNPTLKESK IRLKFKEIQK SKEKLTTRVT 300
EEEFCEAFCE LCTRPEVYFL LVQISKNKEY LDANDLMLFL EAEQGVTHIT EDMCLDIIRR 360
YELSEDGRQK GFLAIDGFTQ YLLSPECDIF DPEQKKVAQD MTQPLSHYYI NASHNTYLIE 420
DQFRGPADIN GYVRALKMGC RSIELDVSDG PDNEPILCNR NNMAMHLSFR SVLEVINKFA 480
FVASEYPLIL CLGNHCSLPQ QKVMAQQMKK VFGEKLYTEA PLSSESYLPS PEKLKNMIIV 540
KGKKLPSESD LLEGEVTDED EEAEMSRRMS GDYNGEQKHI WLCRELSDLV SICKSVQHRD 600
FELSMKTQNY WEMCSFSETE ASRIANEYPE DFVNYNKKFL SRVYPSAMRI DSSNLNPQDF 660
WNCGCQIVAM NFQTPGPMMD LHTGWFLQNG GCGYVLRPSI MRDEVSYFSA NTKGIVPGVS 720
PLVLHIKIIS GQNFPKPKGA CAKGDVIDPY VCVEIHGIPA DCCEQRTKTV QQNSDNPIFD 780
ETFEFQVNLP ELTMVRFVIL DDDYIGDEFI GQYTIPFECL QPGYRHVPLR SFVGDIMEHV 840
TLFVHIAITN RSGGGKPQKR SLSVRMGKKV REYTMLRNIG LKTIDDIFKI AVHPLREAID 900
MRENMQNAIV SVKELCGLPP IASLKQCLLT LSSRLITSDS TPSVSLVMKD CFPYLEPLGA 960
IPDVQKRMLA AYDLMIQESR VLIEMADTVQ EKIVQCQKAG MEFHEELHNL GAKEGLKGRK 1020
LNKAIESFAW NITVLKGQGD LLKNAKNEAV ENIKQIQLAC LSCGLSKGPG GGSEAKGKRS 1080
LEAIEEKESS EENGKL 1096 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0050811; F:GABA receptor binding; TAS:MGI. GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0006629; P:lipid metabolic process; IEA:InterPro. GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |