CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020766
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation elongation factor 1 epsilon-1 
Protein Synonyms/Alias
 Elongation factor p18; Multisynthase complex auxiliary component p18 
Gene Name
 Eef1e1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
21LGLKPGNKYSAQGERubiquitination[1]
138LTVQEKEKYLNVSRWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Positive modulator of ATM response to DNA damage (By similarity). 
Sequence Annotation
 DOMAIN 50 173 GST C-terminal.
 REGION 2 56 N-terminal (By similarity).
 REGION 57 63 Linker (By similarity).
 REGION 64 152 C-terminal (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 138 138 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 174 AA 
Protein Sequence
MAAAAELRLL EKSLGLKPGN KYSAQGERQI PVLQTNNGPS LMGLSTIATH LVKQASKEHL 60
LGSTAEEKAM VQQWLEFRVT RVDGHSSKED TQTLLKDLNS YLEDKVYLAG HNITLADILL 120
YYGLHRFIVD LTVQEKEKYL NVSRWFCHIQ HYPDIRQHLS SIVFIKNRLY ANSH 174 
Gene Ontology
 GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; NAS:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0006281; P:DNA repair; NAS:UniProtKB.
 GO:0009790; P:embryo development; NAS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IMP:UniProtKB.
 GO:0006412; P:translation; IEA:UniProtKB-KW. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF00043; GST_C 
SMART
  
PROSITE
 PS50405; GST_CTER 
PRINTS