CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dual specificity protein phosphatase 9 
Protein Synonyms/Alias
 Mitogen-activated protein kinase phosphatase 4; MAP kinase phosphatase 4; MKP-4 
Gene Name
 DUSP9 
Gene Synonyms/Alias
 MKP4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
321NDAYDLVKRKKSNISubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Inactivates MAP kinases. Has a specificity for the ERK family. 
Sequence Annotation
 DOMAIN 18 139 Rhodanese.
 DOMAIN 203 384 Tyrosine-protein phosphatase.
 ACT_SITE 290 290 Phosphocysteine intermediate (By
 MOD_RES 351 351 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 384 AA 
Protein Sequence
MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 60
VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 120
YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR 180
DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 240
PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV 300
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 360
SAASNPPSFF TTPTSDGAFE LAPT 384 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0007254; P:JNK cascade; TAS:ProtInc.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR008343; MKP.
 IPR001763; Rhodanese-like_dom.
 IPR000387; Tyr/Dual-sp_Pase. 
Pfam
 PF00782; DSPc
 PF00581; Rhodanese 
SMART
 SM00195; DSPc
 SM00450; RHOD 
PROSITE
 PS50206; RHODANESE_3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS
 PR01764; MAPKPHPHTASE.