UniProt Accession

 ES1_HUMAN; P30042; A6NFJ6; A6NJY7; O00650; O00660; O15011; O15012; P55346; P78474; Q92505; Q92507 

Genbank Protein ID

 D86061; D86062; U53003; U53007; U53004; U53005; U53006; Y07572; BC002370; BC003587; AP001753; AB001517; AB001517; D86060 

Genbank Nucleotide ID

 BAA12984.1; BAA12985.1; AAC50937.1; AAC50938.1; AAC50938.1; AAC50938.1; AAC50938.1; CAA68857.1; AAH02370.1; AAH03587.1; BAA95554.1; BAA21138.1; BAA21139.1; BAA20888.1 

Protein Name

 ES1 protein homolog, mitochondrial 

Protein Synonyms/Alias

 Protein GT335; Protein KNP-I 

Gene Name

 C21orf33 

Gene Synonyms/Alias

 HES1; KNPI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	SARIARGKITDLANL	ubiquitination	[1, 2]
141	PGGFGAAKNLSTFAV	ubiquitination	[1, 2]
164	KEVERVLKEFHQAGK	acetylation	[3]
185	IAPVLAAKVLRGVEV	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

  

Sequence Annotation

 MOD_RES 219 219 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 268 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IBA:RefGenome. 

Interpro

 IPR002818; ThiJ/PfpI. 

Pfam

 PF01965; DJ-1_PfpI 

SMART

  

PROSITE

  

PRINTS