CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003804
UniProt Accession
Genbank Protein ID
 X06546 
Genbank Nucleotide ID
Protein Name
 Myosin-11 
Protein Synonyms/Alias
 Myosin heavy chain 11; Myosin heavy chain, gizzard smooth muscle 
Gene Name
 MYH11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Gallus gallus (Chicken) 
NCBI Taxa ID
 9031 
Lysine Modification
Position
Peptide
Type
References
128CVVINPYKQLPIYSEmethylation[1]
Reference
 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 
Functional Description
 Muscle contraction. 
Sequence Annotation
 DOMAIN 2 791 Myosin head-like.
 DOMAIN 792 821 IQ.
 NP_BIND 177 184 ATP.
 REGION 667 689 Actin-binding.
 REGION 768 782 Actin-binding.
 REGION 850 1979 Rodlike tail (S2 and LMM domains).
 MOD_RES 2 2 Blocked amino end (Ser).
 MOD_RES 128 128 N6,N6,N6-trimethyllysine.  
Keyword
 3D-structure; Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Motor protein; Muscle protein; Myosin; Nucleotide-binding; Reference proteome; Thick filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1979 AA 
Protein Sequence
MSQKPLSDDE KFLFVDKNFV NNPLAQADWS AKKLVWVPSE KHGFEAASIK EEKGDEVTVE 60
LQENGKKVTL SKDDIQKMNP PKFSKVEDMA ELTCLNEASV LHNLRERYFS GLIYTYSGLF 120
CVVINPYKQL PIYSEKIIDM YKGKKRHEMP PHIYAIADTA YRSMLQDRED QSILCTGESG 180
AGKTENTKKV IQYLAVVASS HKGKKDTSIT QGPSFSYGEL EKQLLQANPI LEAFGNAKTV 240
KNDNSSRFGK FIRINFDVTG YIVGANIETY LLEKSRAIRQ AKDERTFHIF YYLIAGASEQ 300
MRNDLLLEGF NNYTFLSNGH VPIPAQQDDE MFQETLEAMT IMGFTEEEQT SILRVVSSVL 360
QLGNIVFKKE RNTDQASMPD NTAAQKVCHL MGINVTDFTR SILTPRIKVG RDVVQKAQTK 420
EQADFAIEAL AKAKFERLFR WILTRVNKAL DKTKRQGASF LGILDIAGFE IFEINSFEQL 480
CINYTNEKLQ QLFNHTMFIL EQEEYQREGI EWNFIDFGLD LQPCIELIER PTNPPGVLAL 540
LDEECWFPKA TDTSFVEKLI QEQGNHAKFQ KSKQLKDKTE FCILHYAGKV TYNASAWLTK 600
NMDPLNDNVT SLLNQSSDKF VADLWKDVDR IVGLDQMAKM TESSLPSASK TKKGMFRTVG 660
QLYKEQLTKL MTTLRNTNPN FVRCIIPNHE KRAGKLDAHL VLEQLRCNGV LEGIRICRQG 720
FPNRIVFQEF RQRYEILAAN AIPKGFMDGK QACILMIKAL ELDPNLYRIG QSKIFFRTGV 780
LAHLEEERDL KITDVIIAFQ AQCRGYLARK AFAKRQQQLT AMKVIQRNCA AYLKLRNWQW 840
WRLFTKVKPL LQVTRQEEEM QAKDEELQRT KERQQKAEAE LKELEQKHTQ LCEEKNLLQE 900
KLQAETELYA EAEEMRVRLA AKKQELEEIL HEMEARIEEE EERSQQLQAE KKKMQQQMLD 960
LEEQLEEEEA ARQKLQLEKV TADGKIKKME DDILIMEDQN NKLTKERKLL EERVSDLTTN 1020
LAEEEEKAKN LTKLKNKHES MISELEVRLK KEEKSRQELE KIKRKLEGES SDLHEQIAEL 1080
QAQIAELKAQ LAKKEEELQA ALARLEDETS QKNNALKKIR ELESHISDLQ EDLESEKAAR 1140
NKAEKQKRDL SEELEALKTE LEDTLDTTAT QQELRAKREQ EVTVLKRALE EETRTHEAQV 1200
QEMRQKHTQA VEELTEQLEQ FKRAKANLDK TKQTLEKDNA DLANEIRSLS QAKQDVEHKK 1260
KKLEVQLQDL QSKYSDGERV RTELNEKVHK LQIEVENVTS LLNEAESKNI KLTKDVATLG 1320
SQLQDTQELL QEETRQKLNV TTKLRQLEDD KNSLQEQLDE EVEAKQNLER HISTLTIQLS 1380
DSKKKLQEFT ATVETMEEGK KKLQREIESL TQQFEEKAAS YDKLEKTKNR LQQELDDLVV 1440
DLDNQRQLVS NLEKKQKKFD QMLAEEKNIS SKYADERDRA EAEAREKETK ALSLARALEE 1500
ALEAKEELER TNKMLKAEME DLVSSKDDVG KNVHELEKSK RTLEQQVEEM KTQLEELEDE 1560
LQAAEDAKLR LEVNMQAMKS QFERDLQARD EQNEEKRRQL LKQLHEHETE LEDERKQRAL 1620
AAAAKKKLEV DVKDLESQVD SANKAREEAI KQLRKLQAQM KDYQRDLDDA RAAREEIFAT 1680
ARENEKKAKN LEAELIQLQE DLAAAERARK QADLEKEEMA EELASANSGR TSLQDEKRRL 1740
EARIAQLEEE LDEEHSNIET MSDRMRKAVQ QAEQLNNELA TERATAQKNE NARQQLERQN 1800
KELRSKLQEM EGAVKSKFKS TIAALEAKIA SLEEQLEQEA REKQAAAKTL RQKDKKLKDA 1860
LLQVEDERKQ AEQYKDQAEK GNLRLKQLKR QLEEAEEESQ RINANRRKLQ RELDEATESN 1920
DALGREVAAL KSKLRRGNEP VSFAPPRRSG GRRVIENATD GGEEEIDGRD GDFNGKASE 1979 
Gene Ontology
 GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
 GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0008307; F:structural constituent of muscle; ISS:UniProtKB.
 GO:0048739; P:cardiac muscle fiber development; ISS:UniProtKB.
 GO:0048251; P:elastic fiber assembly; ISS:UniProtKB.
 GO:0030241; P:skeletal muscle myosin thick filament assembly; ISS:UniProtKB.
 GO:0006939; P:smooth muscle contraction; ISS:UniProtKB. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.