CPLM-001571

Genbank Nucleotide ID

Myelin protein zero-like protein 1

Protein Synonyms/Alias

Protein zero-related

Homo sapiens (Human)

Position	Peptide	Type	References
115	SWAGDLDKKDASINI	ubiquitination	[1, 2]
116	WAGDLDKKDASINIE	ubiquitination	[3]
138	GTYICDVKNPPDIVV	ubiquitination	[3]
213	SESLSPVKQAPRKSP	ubiquitination	[1, 3, 4, 5]
218	PVKQAPRKSPSDTEG	ubiquitination	[3]
228	SDTEGLVKSLPSGSH	ubiquitination	[3, 5]
257	HHSDKINKSESVVYA	ubiquitination	[1, 6]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]

Functional Description

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

DOMAIN 36 146 Ig-like V-type.
MOTIF 239 244 ITIM motif 1.
MOTIF 261 266 ITIM motif 2.
MOD_RES 208 208 Phosphoserine.
MOD_RES 210 210 Phosphoserine.
MOD_RES 219 219 Phosphoserine.
MOD_RES 221 221 Phosphoserine.
MOD_RES 241 241 Phosphotyrosine.
MOD_RES 260 260 Phosphoserine.
MOD_RES 263 263 Phosphotyrosine.
CARBOHYD 50 50 N-linked (GlcNAc...).
CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
DISULFID 58 135 By similarity.

Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005198; F:structural molecule activity; TAS:ProtInc.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc.

IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR013106; Ig_V-set.
IPR003596; Ig_V-set_subgr.
IPR000920; Myelin_P0.