| Tag | Content |
|---|
| CPLM ID | CPLM-005186 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear transcription factor Y subunit alpha |
Protein Synonyms/Alias | CAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YA |
Gene Name | NFYA |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 270 | EPLYVNAKQYHRILK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. |
Sequence Annotation | DNA_BIND 296 321 NFYA/HAP2-type.
MOTIF 266 289 Subunit association domain (SAD).
MOD_RES 326 326 Phosphoserine. |
Keyword | 3D-structure; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 347 AA |
Protein Sequence | MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ TLQVVQGQPL 60
MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG LQQIQLVPPG QIQIQGGQAV 120
QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ QIAVQGQQVA QTAEGQTIVY QPVNADGTIL 180
QQVTVPVSGM ITIPAASLAG AQIVQTGANT NTTSSGQGTV TVTLPVAGNV VNSGGMVMMV 240
PGAGSVPAIQ RIPLPGAEML EEEPLYVNAK QYHRILKRRQ ARAKLEAEGK IPKERRKYLH 300
ESRHRHAMAR KRGEGGRFFS PKEKDSPHMQ DPNQADEEAM TQIIRVS 347 |
Gene Ontology | GO:0016602; C:CCAAT-binding factor complex; IDA:UniProtKB. GO:0003677; F:DNA binding; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0044255; P:cellular lipid metabolic process; TAS:Reactome. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0044281; P:small molecule metabolic process; TAS:Reactome. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
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PROSITE | |
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