UniProt Accession

 PDXB_ECOLI; P05459 

Genbank Protein ID

 M29962; U76961; U00096; AP009048; X02743; M15541 

Genbank Nucleotide ID

 AAA24308.1; AAB36530.1; AAC75380.1; BAA16177.1; CAA26520.1; AAA24310.1 

Protein Name

 Erythronate-4-phosphate dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 pdxB 

Gene Synonyms/Alias

 b2320; JW2317 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
48	LMVRSVTKVNESLLA	acetylation	[1]
57	NESLLAGKPIKFVGT	acetylation	[1]
141	RLEALGIKTLLCDPP	acetylation	[1]
179	TFHTPLFKDGPYKTL	acetylation	[1]
184	LFKDGPYKTLHLADE	acetylation	[1]
192	TLHLADEKLIRSLKP	acetylation	[1]
263	AGYTLEGKARGTTQV	acetylation	[1]
338	GIPGEFDKLRKNYLE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity). 

Sequence Annotation

 ACT_SITE 208 208 By similarity.
 ACT_SITE 237 237 By similarity.
 ACT_SITE 254 254 Proton donor (By similarity).
 BINDING 45 45 Substrate (By similarity).
 BINDING 66 66 Substrate (By similarity).
 BINDING 146 146 NAD (By similarity).
 BINDING 175 175 NAD; via carbonyl oxygen (By similarity).
 BINDING 232 232 NAD (By similarity).
 BINDING 257 257 NAD; via amide nitrogen (By similarity).
 BINDING 258 258 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; NAD; Oxidoreductase; Pyridoxine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 378 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0033711; F:4-phosphoerythronate dehydrogenase activity; IDA:EcoCyc.
 GO:0051287; F:NAD binding; IDA:EcoCyc.
 GO:0042823; P:pyridoxal phosphate biosynthetic process; IDA:EcoCyc.
 GO:0008615; P:pyridoxine biosynthetic process; IDA:EcoCyc. 

Interpro

 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR020921; Erythronate-4-P_DHase.
 IPR024531; Erythronate-4-P_DHase_dimer.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C
 PF11890; DUF3410 

SMART

  

PROSITE

 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS