CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013831
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Minor histocompatibility protein HA-1 
Protein Synonyms/Alias
  
Gene Name
 HMHA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 
NCBI Taxa ID
 9601 
Lysine Modification
Position
Peptide
Type
References
511KQELEDTKVTALRQIubiquitination[1]
764ECCLACHKKCLETLAubiquitination[2]
765CCLACHKKCLETLAIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 GTPase activator for the Rho-type GTPases (Potential). 
Sequence Annotation
 DOMAIN 788 1001 Rho-GAP.
 ZN_FING 729 774 Phorbol-ester/DAG-type.
 MOD_RES 23 23 Phosphoserine (By similarity).
 MOD_RES 25 25 Phosphoserine (By similarity).
 MOD_RES 100 100 Phosphoserine (By similarity).
 MOD_RES 120 120 Phosphoserine (By similarity).
 MOD_RES 126 126 Phosphoserine (By similarity).
 MOD_RES 596 596 Phosphoserine (By similarity).
 MOD_RES 605 605 Phosphoserine (By similarity).
 MOD_RES 646 646 Phosphoserine (By similarity).
 MOD_RES 1054 1054 Phosphoserine (By similarity).
 MOD_RES 1057 1057 Phosphoserine (By similarity).
 MOD_RES 1059 1059 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; GTPase activation; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1163 AA 
Protein Sequence
MFSRKKRELM KTPSISKKNR AGSPSPQPSG PHFISGETEA VSRPENPFNE LPSDLPKELP 60
RKDGADAVFP GTSLELPAGS SGVKATGTLK RPTSLSRHAS AAGFPLSGAA SWTLGRSHRS 120
PLTAASPGEL PTEGTGPDVV EDISHLLADV ARFAEGLEKL KECVLRDDLL EARRPLAHEC 180
LGEALRVMRQ IISKYPLLNT VETLTAAGTL IAKVKAFHYE SNNDLEKQEF EKALETIAVA 240
FSSAVSEFLM GEVDSSTLLA VPPGDSSQSM ESLYGSGSEG TPPSLDDCDA GCLPAEEVDV 300
LLQRCEGGVD AALLYAKNMA KYMKDLISYL EKRTTLEMEF AKGLQKMAHN CRQSVTQEPH 360
MPLLSIYSLA LEQDLEFGHG MVQAVGTLQT QTFMQPLTLR RLEHEKRRKE IKEAWHRAQR 420
KLQEAESNLR KAKQGYTQRC EDHDKARFLV AKAEEEQAGT APGAGSTATK TLDKRRRLEE 480
EAKNKAEEAM ATYRTCVADA KTQKQELEDT KVTALRQIQE VIRQSDQTIK SATISYYQMM 540
HMQTAPLPVH FQMLCESSKL YDPGQQYASH VRQLQRDQEP DVHYDFEPHV SANAWSPVMR 600
ARKSSFNVSD VAGPEAAGSP PEEGGCIEGT PVKGHRAGRG HQVHKSWPLS ISDSASGLDP 660
GPGAGDFKKF ERTSSSGTMS STEELVDPEG GAGASAFEQA DLNGMTPELP VAVPSGPFRH 720
EGLSKAARTH RLRKLRTPAK CRECNSYVYF QGAECEECCL ACHKKCLETL AIQCGHKKLQ 780
GRLQLFGQDF SHAARSAPDG VPFIVKKCVC EIERRALRTK GIYRVNGVKT RVEKLCQAFE 840
NGKELVELSQ ASPHDISNVL KLYLRQLPEP LISFRLYHEL VGLAKDSLKA EAEAKAASRG 900
RQDSSESEAV AVAMAGRLRE LLRDLPPENR ASLQYLLRHL RRIVEVEQDN KMTPGNLGIV 960
FGPTLLRPRP TEATVSLSSL VDYPHQARVI ETLIVHYGLV FEEEPEEIPG GQDESSNQRA 1020
EVVVQVPYLE AGEGVVYPLQ EAAEDGCRES RVVSNDSDSD LEEASELLSS SEASALCRLS 1080
FLEQQQSEAS LEEASGSHSG SEEQLETTAR EDGDGDEDSP AQRLSGFNTN QSNNVLQTPL 1140
PPMRLRGGRI TLGSCRERQP EFV 1163 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. 
Interpro
 IPR001060; FCH_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00620; RhoGAP 
SMART
 SM00109; C1
 SM00055; FCH
 SM00324; RhoGAP 
PROSITE
 PS50238; RHOGAP
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS