| Tag | Content |
|---|
| CPLM ID | CPLM-013711 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | S-adenosylmethionine synthase |
Protein Synonyms/Alias | AdoMet synthase; MAT; Methionine adenosyltransferase |
Gene Name | metK |
Gene Synonyms/Alias | GK2849 |
Created Date | July 27, 2013 |
Organism | Geobacillus kaustophilus (strain HTA426) |
NCBI Taxa ID | 235909 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 84 | EIGYTRAKYGFDADT | acetylation | [1] | | 223 | DIKEQVIKPVVPAEL | acetylation | [1] | | 260 | DAGLTGRKIIVDTYG | acetylation | [1] | | 389 | LPWERTDKAALLKEQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus. Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG. Proteomics. 2013 Aug;13(15):2278-82. [ PMID: 23696451] |
Functional Description | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (By similarity). |
Sequence Annotation | NP_BIND 274 281 ATP (Potential).
METAL 19 19 Magnesium (By similarity).
METAL 45 45 Potassium (By similarity).
METAL 278 278 Potassium (By similarity).
METAL 286 286 Magnesium (By similarity). |
Keyword | ATP-binding; Cobalt; Complete proteome; Cytoplasm; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Potassium; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 403 AA |
Protein Sequence | MSAKRRLFTS ESVTEGHPDK ICDQISDAIL DAILEKDPNA RVACETSVTT GLVLVSGEIT 60
TSTYVDIPRI VRDTVREIGY TRAKYGFDAD TCAVLTSIDE QSPDIAMGVD RALEAREGQM 120
TDEEIEAIGA GDQGLMFGFA CNETEELMPM PISLAHRLAR RLAEVRKTDV LPYLRPDGKT 180
QVTIEYDENG KPVRVDTIVV SAQHHPEITQ EQIQRDIKEQ VIKPVVPAEL LDENTKYFIN 240
PTGRFVIGGP QGDAGLTGRK IIVDTYGGYA RHGGGAFSGK DPTKVDRSAA YAARYVAKNI 300
VAAGLADKCE VQLAYAIGVA RPVSISIDTF GTGKVSEDIL IEVVRNNFDL RPAGIIKMLD 360
LRRPIYKQTA AYGHFGRTDI DLPWERTDKA ALLKEQALAL ADK 403 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0000287; F:magnesium ion binding; IEA:HAMAP. GO:0004478; F:methionine adenosyltransferase activity; IEA:HAMAP. GO:0006730; P:one-carbon metabolic process; IEA:HAMAP. GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |