UniProt Accession

 EMR2_HUMAN; Q9UHX3; B4DQ96; E7ESD7; E9PBR1; E9PEL6; E9PFQ5; E9PG91; Q8NG96; Q9Y4B1 

Genbank Protein ID

 AF114491; AB065931; AK298700; AC004262; AC005327; AC090427 

Genbank Nucleotide ID

 AAF21974.1; BAC06146.1; BAG60858.1; AAC05172.1 

Protein Name

 EGF-like module-containing mucin-like hormone receptor-like 2 

Protein Synonyms/Alias

 EGF-like module receptor 2; CD312 

Gene Name

 EMR2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
813	HTLSSSAKADTSKPS	ubiquitination	[1]
818	SAKADTSKPSTVN**	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. 

Sequence Annotation

 DOMAIN 25 66 EGF-like 1.
 DOMAIN 67 118 EGF-like 2; calcium-binding.
 DOMAIN 119 162 EGF-like 3; calcium-binding.
 DOMAIN 163 211 EGF-like 4; calcium-binding (Potential).
 DOMAIN 212 260 EGF-like 5; calcium-binding (Potential).
 DOMAIN 479 529 GPS.
 CARBOHYD 41 41 N-linked (GlcNAc...) (Potential).
 CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 CARBOHYD 354 354 N-linked (GlcNAc...) (Potential).
 CARBOHYD 456 456 N-linked (GlcNAc...) (Potential).
 CARBOHYD 460 460 N-linked (GlcNAc...) (Potential).
 DISULFID 29 39
 DISULFID 33 45
 DISULFID 47 65
 DISULFID 71 85
 DISULFID 79 94
 DISULFID 96 117
 DISULFID 123 136
 DISULFID 130 145
 DISULFID 147 161 By similarity.
 DISULFID 167 180 By similarity.
 DISULFID 174 189 By similarity.
 DISULFID 191 210 By similarity.
 DISULFID 216 229 By similarity.
 DISULFID 223 238 By similarity.
 DISULFID 240 259 By similarity.  

Keyword

 3D-structure; Alternative splicing; Autocatalytic cleavage; Calcium; Cell adhesion; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; G-protein coupled receptor; Glycoprotein; Inflammatory response; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 823 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; TAS:GDB.
 GO:0031256; C:leading edge membrane; IDA:UniProtKB.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0035374; F:chondroitin sulfate binding; IMP:UniProtKB.
 GO:0004930; F:G-protein coupled receptor activity; TAS:GDB.
 GO:0007155; P:cell adhesion; IMP:UniProtKB.
 GO:0071621; P:granulocyte chemotaxis; IMP:UniProtKB.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. 

Interpro

 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR017981; GPCR_2-like.
 IPR003056; GPCR_2_CD97.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom. 

Pfam

 PF00002; 7tm_2
 PF07645; EGF_CA
 PF01825; GPS 

SMART

 SM00179; EGF_CA
 SM00303; GPS 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS 

PRINTS

 PR01278; CD97PROTEIN.
 PR00249; GPCRSECRETIN.