UniProt Accession

 PPP6_HUMAN; O00743; B2R5V6; B7Z2W9; B7Z5K9; Q5U0A2; Q9UIC9 

Genbank Protein ID

 X92972; AF035158; AK295190; AK299087; AK312332; BT019708; AL445930; CH471090; BC006990 

Genbank Nucleotide ID

 CAA63549.1; AAD45400.2; BAH12005.1; BAH12945.1; BAG35253.1; AAV38514.1; CAI13677.1; EAW87611.1; AAH06990.1 

Protein Name

 Serine/threonine-protein phosphatase 6 catalytic subunit 

Protein Synonyms/Alias

 PP6C 

Gene Name

 PPP6C 

Gene Synonyms/Alias

 PPP6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MAPLDLDKYVEIARL	ubiquitination	[1]
17	VEIARLCKYLPENDL	ubiquitination	[2]
268	FVHINNLKLICRAHQ	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. 

Sequence Annotation

 ACT_SITE 114 114 Proton donor (By similarity).
 METAL 53 53 Iron (By similarity).
 METAL 55 55 Iron (By similarity).
 METAL 81 81 Iron (By similarity).
 METAL 81 81 Manganese (By similarity).
 METAL 113 113 Manganese (By similarity).
 METAL 163 163 Manganese (By similarity).
 METAL 237 237 Manganese (By similarity).  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Iron; Manganese; Metal-binding; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 305 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; IDA:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:ProtInc.
 GO:0006470; P:protein dephosphorylation; IDA:MGI. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.