CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035019
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone H2B 
Protein Synonyms/Alias
  
Gene Name
 Hist1h2bl 
Gene Synonyms/Alias
 Hist1h2bf; rCG_23123 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
6**MPEPAKSVPAPKKacetylation[1]
12AKSVPAPKKGSKKAVacetylation[1]
13KSVPAPKKGSKKAVTacetylation[1]
16PAPKKGSKKAVTKAQacetylation[1]
17APKKGSKKAVTKAQKacetylation[1]
21GSKKAVTKAQKKDGKacetylation[1]
24KAVTKAQKKDGKKRKacetylation[1]
35KKRKRSRKESYSVYVacetylation[1]
44SYSVYVYKVLKQVHPacetylation[1]
47VYVYKVLKQVHPDTGacetylation[1]
47VYVYKVLKQVHPDTGubiquitination[2]
86SRLAHYNKRSTITSRacetylation[1]
109LLPGELAKHAVSEGTacetylation[1]
109LLPGELAKHAVSEGTubiquitination[2]
117HAVSEGTKAVTKYTSacetylation[1]
117HAVSEGTKAVTKYTSubiquitination[2]
121EGTKAVTKYTSSK**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 
Sequence Annotation
  
Keyword
 Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 126 AA 
Protein Sequence
MPEPAKSVPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 60
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREVQTAVR LLLPGELAKH AVSEGTKAVT 120
KYTSSK 126 
Gene Ontology
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 
Interpro
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 
Pfam
 PF00125; Histone 
SMART
 SM00427; H2B 
PROSITE
 PS00357; HISTONE_H2B 
PRINTS
 PR00621; HISTONEH2B.