CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038882
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Microtubule-associated protein 
Protein Synonyms/Alias
  
Gene Name
 Map2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
275EMPVESKKDEWGLAAubiquitination[1]
530EPEAVSEKREIQGLFacetylation[2]
618PKNQQDEKELLAKASacetylation[2]
797SESPFPAKEYYKNGTubiquitination[1]
1494PSRKLILKPAIKYTRacetylation[2]
1527AQAPSAFKQAKDKVTacetylation[2]
1673NQPLPDLKNVKSKIGacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Microtubule; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1860 AA 
Protein Sequence
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY REEEEGAFGE 60
HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQP 120
AALPLAAEET VNLPPSPPPS PASEQTAALE EDLLTASKME FPEQQKLPSS FAEPLDKEET 180
EFKMQSKPGE DFEHAALVPQ PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI 240
TEPSITVPSI GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED 300
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD KMSLQDTSGS 360
ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV EGFVGENISG EEKGTTDQEK 420
KETSTPSVQE PTLTETEPQT KLEETSKVSI EETVAKEEES LKLKDDKAGV IQTSTEHSFS 480
KEDQKGEEQT IEALKQDSFP ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED 540
IADKSKLEGA GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG 600
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE LPEEPSSPQE 660
RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ RSMSINLPMS CLDSIALGFN 720
FGRGHDLSPL ASDILTNTSG SMDEGDDYLP PTTPAVEKIP CFPIESKEEE DKTEQAKVTG 780
GQTTQVETSS ESPFPAKEYY KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS 840
EAVVAESSTG LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY 900
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS REFDQDRKAN 960
DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE QTSAKELITT KETAPERAEK 1020
GLSSVPEVAE VETTTKADQG LDVAAKKDDQ SPLDIKVSDF GQMASGMSVD AGKTIELKFE 1080
VDQQLTLSSE APQETDSFMG IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES 1140
SGEHESLTME SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ 1200
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG EYDKLLFRSD 1260
TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT VVQTTTDEGE LGSHSVRFAA 1320
PVQPEEERRP YPHDEELEVL MAAEAQAEPK DGSPDAPATP EKEEVPFSEY KTETYDDYKD 1380
ETTIDDSIMD ADSLWVDTQD DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG 1440
RGRISTPERK VAKKEPSTVS RDEVRRKKAV YKKAELAKKS EVQAHSPSRK LILKPAIKYT 1500
RPTHLSCVKR KTTATSGESA QAPSAFKQAK DKVTDGITKS PEKRSSLPRP SSILPPRRGV 1560
SGDREENSFS LNSSISSARR TTRSEPIRRA GKSGTSTPTT PGSTAITPGT PPSYSSRTPG 1620
TPGTPSYPRT PGTPKSGILV PSEKKVAIIR TPPKSPATPK QLRLINQPLP DLKNVKSKIG 1680
STDNIKYQPK GGQVRILNKK IDFSKVQSRC GSKDNIKHSA GGGNVQIVTK KIDLSHVTSK 1740
CGSLKNIRHR PGGGRVKIES VKLDFKEKAQ AKVGSLDNAH HVPGGGNVKI DSQKLNFREH 1800
AKARVDHGAE IITQSPSRSS VASPRRLSNV SSSGSINLLE SPQLATLAED VTAALAKQGL 1860 
Gene Ontology
 GO:0005874; C:microtubule; IEA:UniProtKB-KW. 
Interpro
 IPR027324; MAP2/MAP4/Tau.
 IPR013588; MAP2_projctn.
 IPR001084; Tau/MAP_tubulin-bd_rpt. 
Pfam
 PF08377; MAP2_projctn
 PF00418; Tubulin-binding 
SMART
  
PROSITE
 PS00229; TAU_MAP_1
 PS51491; TAU_MAP_2 
PRINTS