UniProt Accession

 ETV1_HUMAN; P50549; A4D118; B2R768; B7Z2I4; B7Z618; B7Z9P2; C9JT37; E9PHB1; F5GXR2; O75849; Q4KMQ6; Q59GA7; Q6AI30; Q9UQ71; Q9Y636 

Genbank Protein ID

 U17163; X87175; AF109632; AF109621; AF109622; AF109623; AF109624; AF109625; AF109626; AF109627; AF109628; AF109629; AF109630; AF109631; AF109632; AF109621; AF109622; AF109623; AF109625; AF109626; AF109627; AF109628; AF109629; AF109630; AF109631; AK294755; AK299693; AK312863; AK316007; AB209202; CR627389; AC004857; AC004909; CH236948; BC098403; BC106762; BC106763 

Genbank Nucleotide ID

 AAA79844.1; CAA60642.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29877.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; AAD29878.1; BAH11870.1; BAH13104.1; BAG35715.1; BAH14378.1; BAD92439.1; CAH10484.1; AAC62435.1; EAL24294.1; AAH98403.1; AAI06763.1; AAI06764.1 

Protein Name

 ETS translocation variant 1 

Protein Synonyms/Alias

 Ets-related protein 81 

Gene Name

 ETV1 

Gene Synonyms/Alias

 ER81 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	PTNVRKRKFINRDLA	acetylation	[1]
89	HGLPLKIKKEPHSPC	sumoylation	[2]
116	FKFSYGEKCLYNVSA	acetylation	[1, 3]

Reference

 [1] Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
 Goel A, Janknecht R.
 Mol Cell Biol. 2003 Sep;23(17):6243-54. [PMID: 12917345]
 [2] The transactivation function of the Pea3 subfamily Ets transcription factors is regulated by sumoylation.
 Bojović BB, Hassell JA.
 DNA Cell Biol. 2008 Jun;27(6):289-305. [PMID: 18447755]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. 

Sequence Annotation

 DNA_BIND 335 415 ETS.
 MOD_RES 191 191 Phosphoserine; by RPS6KA1 and RPS6KA5.
 MOD_RES 216 216 Phosphoserine; by RPS6KA1 and RPS6KA5.  

Keyword

 3D-structure; Activator; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 477 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0007638; P:mechanosensory behavior; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0048935; P:peripheral nervous system neuron development; TAS:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR000418; Ets_dom.
 IPR006715; ETS_PEA3_N.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF04621; ETS_PEA3_N 

SMART

 SM00413; ETS 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 

PRINTS

 PR00454; ETSDOMAIN.