UniProt Accession

 CRBS_HUMAN; P22914; B2RAF8 

Genbank Protein ID

 AK314172; AF161703; AF242198; AF242197; CH471052; BC069478; BC070241; L36869 

Genbank Nucleotide ID

 BAG36855.1; AAD45901.1; AAF72490.1; AAF72490.1; EAW78195.1; AAH69478.1; AAH70241.1; AAA92870.1 

Protein Name

 Beta-crystallin S 

Protein Synonyms/Alias

 Gamma-S-crystallin; Gamma-crystallin S 

Gene Name

 CRYGS 

Gene Synonyms/Alias

 GRYG8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MSKTGTKITFYEDK	methylation	[1, 2]

Reference

 [1] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Crystallins are the dominant structural components of the vertebrate eye lens. 

Sequence Annotation

 DOMAIN 6 44 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 45 87 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 94 134 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 135 177 Beta/gamma crystallin 'Greek key' 4.
 REGION 2 5 N-terminal arm.
 REGION 88 93 Connecting peptide.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Eye lens protein; Oxidation; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0002009; P:morphogenesis of an epithelium; IEA:Compara. 

Interpro

 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 

Pfam

 PF00030; Crystall 

SMART

 SM00247; XTALbg 

PROSITE

 PS50915; CRYSTALLIN_BETA_GAMMA 

PRINTS

 PR01367; BGCRYSTALLIN.