CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022766
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating 
Protein Synonyms/Alias
  
Gene Name
 Nsdhl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
179VLDANDPKKNFLTAAubiquitination[1]
334YSCEKAKKLFGYRPLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 161 161 Proton acceptor (By similarity).
 BINDING 165 165 NAD (By similarity).  
Keyword
 Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MEQAVHGESK RGQVTGTHLT NDISKAKKCT VIGGSGFLGQ HMVEQLLERG YTVNVFDIHQ 60
GFDNPRVQFF IGDLCNQQDL YPALKGVSTV FHCASPPPYS NNKELFYRVN FIGTKTVIET 120
CREAGVQKLI LTSSASVVFE GVDIKNGTED LPYAMKPIDY YTETKILQER AVLDANDPKK 180
NFLTAAIRPH GIFGPRDPQL VPILIDAARK GKMKFMIGNG ENLVDFTFVE NVVHGHILAA 240
EHLSQDAALG GKAFHITNDE PIPFWTFLSR ILTGLNYEAP KYHIPYWMAY YLAFLLSLLV 300
MVVSPLIQIQ PTFTPIRVAL AGTFHYYSCE KAKKLFGYRP LVTMDEAVER TVQSFHHLRK 360
DK 362 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
 GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
 GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0001942; P:hair follicle development; IMP:MGI.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.
 GO:0007224; P:smoothened signaling pathway; IGI:MGI. 
Interpro
 IPR002225; 3Beta_OHSteriod_DH/Estase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01073; 3Beta_HSD 
SMART
  
PROSITE
  
PRINTS