UniProt Accession

 SUCB2_HUMAN; Q96I99; C9JVT2; O95195; Q6NUH7; Q86VX8; Q8WUQ1 

Genbank Protein ID

 AK310527; AC099783; AC112213; AC113169; AC114401; BC007716; BC019868; BC047024; BC068602; AF058954; AF131748 

Genbank Nucleotide ID

 AAH07716.3; AAH19868.1; AAH47024.1; AAH68602.1; AAC64397.1; AAD20032.1 

Protein Name

 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 

Protein Synonyms/Alias

 GTP-specific succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase beta-G chain; SCS-betaG 

Gene Name

 SUCLG2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	NEALEAAKRLNAKEI	acetylation	[1]
118	NVVGQLAKQMIGYNL	ubiquitination	[2, 3]
227	QAADQITKLYNLFLK	acetylation	[1]
291	PIENEAAKYDLKYIG	acetylation	[1, 4]
338	LDLGGGVKEAQVYQA	acetylation	[1, 4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity). 

Sequence Annotation

 DOMAIN 46 274 ATP-grasp.
 MOD_RES 227 227 N6-acetyllysine.
 MOD_RES 291 291 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; GTP-binding; Ligase; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004776; F:succinate-CoA ligase (GDP-forming) activity; NAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006104; P:succinyl-CoA metabolic process; NAS:UniProtKB.
 GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome. 

Interpro

 IPR013650; ATP-grasp_succ-CoA_synth-type.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR005811; CoA_ligase.
 IPR017866; Succ-CoA_synthase_bsu_CS.
 IPR005809; Succ_CoA_synthase_bsu.
 IPR016102; Succinyl-CoA_synth-like. 

Pfam

 PF08442; ATP-grasp_2
 PF00549; Ligase_CoA 

SMART

  

PROSITE

 PS50975; ATP_GRASP
 PS01217; SUCCINYL_COA_LIG_3 

PRINTS