CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ABC transporter ATP-binding protein ARB1 
Protein Synonyms/Alias
 ATP-binding cassette protein involved in ribosome biogenesis 1 
Gene Name
 ARB1 
Gene Synonyms/Alias
 YER036C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
61MMKLQQDKDGLSDRVubiquitination[1]
125CGKSTFLKALATREYacetylation[2]
125CGKSTFLKALATREYubiquitination[1]
239KMRVALAKALFVKPTacetylation[2]
313GNYDSYHKTRSELETacetylation[2]
362SRQKILDKMEADGLVacetylation[2]
439VGKSTLLKIMTGELTacetylation[2]
439VGKSTLLKIMTGELTubiquitination[1]
588DIFVVENKTATRWDGubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Stimulates 40S and 60S ribosome biogenesis. 
Sequence Annotation
 DOMAIN 82 323 ABC transporter 1.
 DOMAIN 393 610 ABC transporter 2.
 NP_BIND 114 121 ATP 1 (Potential).
 NP_BIND 428 435 ATP 2 (Potential).
 MOD_RES 43 43 Phosphoserine.
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.
 MOD_RES 446 446 Phosphothreonine.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 610 AA 
Protein Sequence
MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR EIKMMKLQQD 60
KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS GLELNYGRRY GLLGENGCGK 120
STFLKALATR EYPIPEHIDI YLLDEPAEPS ELSALDYVVT EAQHELKRIE DLVEKTILED 180
GPESELLEPL YERMDSLDPD TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA 240
LFVKPTLLLL DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK 300
LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV KQAKSRQKIL 360
DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF HYESNPSENL YEHLNFGVDM 420
DSRIALVGPN GVGKSTLLKI MTGELTPQSG RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF 480
VRDKYSNISQ DFQFWRGQLG RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD 540
EPTNGLDIPT IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY 600
KNKLAKNVVL 610 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042624; F:ATPase activity, uncoupled; IMP:SGD.
 GO:0000056; P:ribosomal small subunit export from nucleus; IMP:SGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS