CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017149
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myocardin 
Protein Synonyms/Alias
  
Gene Name
 MYOCD 
Gene Synonyms/Alias
 MYCD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
571PFLAASIKQEEAVSSsumoylation[1]
Reference
 [1] Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts.
 Wang J, Li A, Wang Z, Feng X, Olson EN, Schwartz RJ.
 Mol Cell Biol. 2007 Jan;27(2):622-32. [PMID: 17101795] 
Functional Description
 Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). 
Sequence Annotation
 REPEAT 18 43 RPEL 1.
 REPEAT 62 87 RPEL 2.
 REPEAT 106 131 RPEL 3.
 DOMAIN 371 405 SAP.
 REGION 153 205 HDAC5-binding (By similarity).
 MOTIF 12 27 MEF2C-binding (By similarity).
 MOD_RES 451 451 Phosphoserine; by GSK3-beta (By
 MOD_RES 455 455 Phosphoserine; by GSK3-beta (By
 MOD_RES 459 459 Phosphoserine; by GSK3-beta (By
 MOD_RES 463 463 Phosphoserine; by GSK3-beta (By
 MOD_RES 626 626 Phosphoserine; by GSK3-beta (By
 MOD_RES 630 630 Phosphoserine; by GSK3-beta (By
 MOD_RES 634 634 Phosphoserine; by GSK3-beta (By
 MOD_RES 638 638 Phosphoserine; by GSK3-beta (By
 MOD_RES 815 815 Phosphoserine; by MAPK1 AND MAPK3 (By
 MOD_RES 862 862 Phosphoserine; by MAPK1 and MAPK3 (By
 MOD_RES 869 869 Phosphoserine; by MAPK1 and MAPK3 (By
 MOD_RES 896 896 Phosphothreonine; by MAPK1 and MAPK3 (By  
Keyword
 Activator; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 938 AA 
Protein Sequence
MTLLGSEHSL LIRSKFRSVL QLRLQQRRTQ EQLANQGIIP PLKRPAEFHE QRKHLDSDKA 60
KNSLKRKARN RCNSADLVNM HILQASTAER SIPTAQMKLK RARLADDLNE KIALRPGPLE 120
LVEKNILPVD SAVKEAIKGN QVSFSKSTDA FAFEEDSSSD GLSPDQTRSE DPQNSAGSPP 180
DAKASDTPST GSLGTNQDLA SGSENDRNDS ASQPSHQSDA GKQGLGPPST PIAVHAAVKS 240
KSLGDSKNRH KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ 300
ILSQQQQQQQ HRFSYLGMHQ AQLKEPNEQM VRNPNSSSTP LSNTPLSPVK NSFSGQTGVS 360
SFKPGPLPPN LDDLKVSELR QQLRIRGLPV SGTKTALMDR LRPFQDCSGN PVPNFGDITT 420
VTFPVTPNTL PNYQSSSSTS ALSNGFYHFG STSSSPPISP ASSDLSVAGS LPDTFNDASP 480
SFGLHPSPVH VCTEESLMSS LNGGSVPSEL DGLDSEKDKM LVEKQKVINE LTWKLQQEQR 540
QVEELRMQLQ KQKRNNCSEK KPLPFLAASI KQEEAVSSCP FASQVPVKRQ SSSSECHPPA 600
CEAAQLQPLG NAHCVESSDQ TNVLSSTFLS PQCSPQHSPL GAVKSPQHIS LPPSPNNPHF 660
LPSSSGAQGE GHRVSSPISS QVCTAQMAGL HSSDKVGPKF SIPSPTFSKS SSAISEVTQP 720
PSYEDAVKQQ MTRSQQMDEL LDVLIESGEM PADAREDHSC LQKVPKIPRS SRSPTAVLTK 780
PSASFEQASS GSQIPFDPYA TDSDEHLEVL LNSQSPLGKM SDVTLLKIGS EEPHFDGIMD 840
GFSGKAAEDL FNAHEILPGP LSPMQTQFSP SSVDSNGLQL SFTESPWETM EWLDLTPPNS 900
TPGFSALTTS SPSIFNIDFL DVTDLNLNSS MDLHLQQW 938 
Gene Ontology
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
 GO:0019904; F:protein domain specific binding; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; ISS:BHF-UCL.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0003231; P:cardiac ventricle development; IEA:Compara.
 GO:0061049; P:cell growth involved in cardiac muscle cell development; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0097070; P:ductus arteriosus closure; IEA:Compara.
 GO:0035733; P:hepatic stellate cell activation; IEA:Compara.
 GO:0048286; P:lung alveolus development; IEA:Compara.
 GO:1900222; P:negative regulation of beta-amyloid clearance; IMP:BHF-UCL.
 GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.
 GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:BHF-UCL.
 GO:0010832; P:negative regulation of myotube differentiation; IEA:Compara.
 GO:2001015; P:negative regulation of skeletal muscle cell differentiation; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IDA:BHF-UCL.
 GO:2000724; P:positive regulation of cardiac vascular smooth muscle cell differentiation; ISS:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0043388; P:positive regulation of DNA binding; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045987; P:positive regulation of smooth muscle contraction; IDA:BHF-UCL.
 GO:0003257; P:positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IDA:BHF-UCL.
 GO:2000721; P:positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; IDA:BHF-UCL.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0001560; P:regulation of cell growth by extracellular stimulus; IEA:Compara.
 GO:0035065; P:regulation of histone acetylation; ISS:UniProtKB.
 GO:0045661; P:regulation of myoblast differentiation; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEP:BHF-UCL.
 GO:0060157; P:urinary bladder development; IEA:Compara.
 GO:0060065; P:uterus development; IEA:Compara.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; IEA:Compara. 
Interpro
 IPR004018; RPEL_repeat.
 IPR003034; SAP_dom. 
Pfam
 PF02755; RPEL
 PF02037; SAP 
SMART
 SM00707; RPEL
 SM00513; SAP 
PROSITE
 PS51073; RPEL
 PS50800; SAP 
PRINTS