| Tag | Content |
|---|
| CPLM ID | CPLM-014888 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | AN1-type zinc finger protein 6 |
Protein Synonyms/Alias | Zinc finger A20 domain-containing protein 3 |
Gene Name | Zfand6 |
Gene Synonyms/Alias | Za20d3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 219 | NPVVVGEKIQKI*** | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). |
Sequence Annotation | ZN_FING 8 42 A20-type.
ZN_FING 161 204 AN1-type. |
Keyword | Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 223 AA |
Protein Sequence | MAQETNHSQA PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP PAASVSSLSE 60
SLPVQCADGS VPDAQSALDS TSSSMQPGPV SNQSLLSESV APSQVDSTSV DKAVSETEDL 120
QGPRAEGLVP LECDPPSSVS DTTQQPSEEQ SKSLEKPKQK KNRCFMCRKK VGLTGFECRC 180
GNVYCGVHRY SDVHNCSYNY KADAAEKIRK ENPVVVGEKI QKI 223 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:InterPro. GO:0031593; F:polyubiquitin binding; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB. GO:0006625; P:protein targeting to peroxisome; ISS:UniProtKB. GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB. GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |