| Tag | Content |
|---|
| CPLM ID | CPLM-001229 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
Protein Synonyms/Alias | AKB ligase; Aminoacetone synthase; Glycine acetyltransferase |
Gene Name | GCAT |
Gene Synonyms/Alias | KBL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 113 | CGTQSIHKNLEAKIA | ubiquitination | [1] | | 118 | IHKNLEAKIARFHQR | ubiquitination | [1] | | 333 | KTQRFRSKMEAAGFT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | |
Sequence Annotation | MOD_RES 265 265 N6-(pyridoxal phosphate)lysine |
Keyword | Acyltransferase; Alternative splicing; Complete proteome; Mitochondrion; Nucleus; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 419 AA |
Protein Sequence | MWPGNAWRAA LFWVPRGRRA QSALAQLRGI LEGELEGIRG AGTWKSERVI TSRQGPHIRV 60
DGVSGGILNF CANNYLGLSS HPEVIQAGLQ ALEEFGAGLS SVRFICGTQS IHKNLEAKIA 120
RFHQREDAIL YPSCYDANAG LFEALLTPED AVLSDELNHA SIIDGIRLCK AHKYRYRHLD 180
MADLEAKLQE AQKHRLRLVA TDGAFSMDGD IAPLQEICCL ASRYGALVFM DECHATGFLG 240
PTGRGTDELL GVMDQVTIIN STLGKALGGA SGGYTTGPGP LVSLLRQRAR PYLFSNSLPP 300
AVVGCASKAL DLLMGSNTIV QSMAAKTQRF RSKMEAAGFT ISGASHPICP VMLGDARLAS 360
RMADDMLKRG IFVIGFSYPV VPKGKARIRV QISAVHSEED IDRCVEAFVE VGRLHGALP 419 |
Gene Ontology | GO:0005739; C:mitochondrion; NAS:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008890; F:glycine C-acetyltransferase activity; NAS:UniProtKB. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0009058; P:biosynthetic process; IEA:InterPro. GO:0006520; P:cellular amino acid metabolic process; NAS:UniProtKB. GO:0019518; P:L-threonine catabolic process to glycine; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |