UniProt Accession

 PGTB1_HUMAN; P53609; Q5MJP9 

Genbank Protein ID

 L25441; AY780790; AC008494 

Genbank Nucleotide ID

 AAA35888.1; AAV98360.1 

Protein Name

 Geranylgeranyl transferase type-1 subunit beta 

Protein Synonyms/Alias

 Geranylgeranyl transferase type I subunit beta; GGTase-I-beta; Type I protein geranyl-geranyltransferase subunit beta 

Gene Name

 PGGT1B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
144	DDLSRVNKEACLAGL	ubiquitination	[1]
195	WSGMDMKKAITYIRR	ubiquitination	[1]
243	LEEVFSEKELNRIKR	ubiquitination	[2]
293	FQYTNFEKNRNYILS	ubiquitination	[1]
367	SWKTKDSKQCSENVH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding. 

Sequence Annotation

 REPEAT 144 186 PFTB 1.
 REPEAT 193 234 PFTB 2.
 REPEAT 245 284 PFTB 3.
 REPEAT 291 333 PFTB 4.
 METAL 269 269 Zinc (By similarity).
 METAL 271 271 Zinc (By similarity).
 METAL 321 321 Zinc (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Metal-binding; Polymorphism; Prenyltransferase; Reference proteome; Repeat; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0005953; C:CAAX-protein geranylgeranyltransferase complex; TAS:ProtInc.
 GO:0004662; F:CAAX-protein geranylgeranyltransferase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IEA:Compara.
 GO:0045787; P:positive regulation of cell cycle; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0018344; P:protein geranylgeranylation; TAS:ProtInc.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara. 

Interpro

 IPR001330; Prenyltrans.
 IPR008930; Terpenoid_cyclase/PrenylTrfase. 

Pfam

 PF00432; Prenyltrans 

SMART

  

PROSITE

  

PRINTS