CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011472
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-dependent kinase 18 
Protein Synonyms/Alias
 Cell division protein kinase 18; PCTAIRE-motif protein kinase 3; Serine/threonine-protein kinase PCTAIRE-3 
Gene Name
 CDK18 
Gene Synonyms/Alias
 PCTAIRE3; PCTK3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
144GKLETYVKLDKLGEGubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May play a role in signal transduction cascades in terminally differentiated cells. 
Sequence Annotation
 DOMAIN 142 423 Protein kinase.
 NP_BIND 148 156 ATP (By similarity).
 ACT_SITE 263 263 Proton acceptor (By similarity).
 BINDING 171 171 ATP (By similarity).
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 72 72 Phosphoserine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 115 115 Phosphoserine.
 MOD_RES 130 130 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 472 AA 
Protein Sequence
MNKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN ENLQLGPLGR DPPQECSTFS 60
PTDSGEEPGQ LSPGVQFQRR QNQRRFSMED VSKRLSLPMD IRLPQEFLQK LQMESPDLPK 120
PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG 180
APCTAIREVS LLKNLKHANI VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV 240
KIFMFQLLRG LAYCHHRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 300
TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL IFRLLGTPTE 360
ETWPGVTAFS EFRTYSFPCY LPQPLINHAP RLDTDGIHLL SSLLLYESKS RMSAEAALSH 420
SYFRSLGERV HQLEDTASIF SLKEIQLQKD PGYRGLAFQQ PGRGKNRRQS IF 472 
Gene Ontology
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
 GO:0004871; F:signal transducer activity; NAS:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS