| Tag | Content |
|---|
| CPLM ID | CPLM-014535 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 12 member 5 |
Protein Synonyms/Alias | Electroneutral potassium-chloride cotransporter 2; Furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2; rKCC2; Neuronal K-Cl cotransporter |
Gene Name | Slc12a5 |
Gene Synonyms/Alias | Kcc2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 59 | INSTDTEKGREYDGR | ubiquitination | [1] | | 895 | DDNSIQMKKDLTTFL | ubiquitination | [1] | | 896 | DNSIQMKKDLTTFLY | ubiquitination | [1] | | 1086 | LNEVIVNKSRDAKLV | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development. |
Sequence Annotation | CARBOHYD 442 442 N-linked (GlcNAc...) (Potential).
CARBOHYD 833 833 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1139 AA |
Protein Sequence | MSRRFTVTSL PPAASAASAD PESRRHSVAD PRRLPREDVK GDGNPKESSP FINSTDTEKG 60
REYDGRNMAL FEEEMDTSPM VSSLLSGLAN YTNLPQGSKE HEEAENNEGG KKKPVQAPRM 120
GTFMGVYLPC LQNIFGVILF LRLTWVVGIA GIMESFCMVF ICCSCTMLTA ISMSAIATNG 180
VVPAGGSYYM ISRSLGPEFG GAVGLCFYLG TTFAGAMYIL GTIEILLAYL FPAMAIFKAE 240
DASGEAAAML NNMRVYGTCV LTCMATVVFV GVKYVNKFAL VFLGCVILSI LAIYAGVIKS 300
AFDPPNFPIC LLGNRTLSRH GFDVCAKLAW EGNETVTTRL WGLFCSSRLL NATCDEYFTR 360
NNVTEIQGIP GAASGLIKEN LWSSYLTKGV IVERRGMPSV GLADGTPVDM DHPYVFSDMT 420
SYFTLLVGIY FPSVTGIMAG SNRSGDLRDA QKSIPTGTIL AIATTSAVYI SSVVLFGACI 480
EGVVLRDKFG EAVNGNLVVG TLAWPSPWVI VIGSFFSTCG AGLQSLTGAP RLLQAISRDG 540
IVPFLQVFGH GKANGEPTWA LLLTACICEI GILIASLDEV APILSMFFLM CYMFVNLACA 600
VQTLLRTPNW RPRFRYYHWT LSFLGMSLCL ALMFICSWYY ALVAMLIAGL IYKYIEYRGA 660
EKEWGDGIRG LSLSAARYAL LRLEEGPPHT KNWRPQLLVL VRVDQDQNVV HPQLLSLTSQ 720
LKAGKGLTIV GSVLEGTFLD NHPQAQRAEE SIRRLMEAEK VKGFCQVVIS SNLRDGVSHL 780
IQSGGLGGLQ HNTVLVGWPR NWRQKEDHQT WRNFIELVRE TTAGHLALLV TKNVSMFPGN 840
PERFSEGSID VWWIVHDGGM LMLLPFLLRH HKVWRKCKMR IFTVAQMDDN SIQMKKDLTT 900
FLYHLRITAE VEVVEMHESD ISAYTYEKTL VMEQRSQILK QMHLTKNERE REIQSITDES 960
RGSIRRKNPA NTRLRLNVPE ETACDNEEKP EEEVQLIHDQ SAPSCPSSSP SPGEEPEGEG 1020
ETDPEKVHLT WTKDKSAAQK NKGPSPVSSE GIKDFFSMKP EWENLNQSNV RRMHTAVRLN 1080
EVIVNKSRDA KLVLLNMPGP PRNRNGDENY MEFLEVLTEQ LDRVMLVRGG GREVITIYS 1139 |
Gene Ontology | GO:0032590; C:dendrite membrane; IDA:RGD. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043204; C:perikaryon; IDA:RGD. GO:0051739; F:ammonia transmembrane transporter activity; IDA:RGD. GO:0015379; F:potassium:chloride symporter activity; IDA:RGD. GO:0015696; P:ammonium transport; IDA:RGD. GO:0051452; P:intracellular pH reduction; IDA:RGD. GO:0006813; P:potassium ion transport; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |