CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031284
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine carboxyl methyltransferase 2 
Protein Synonyms/Alias
 cDNA FLJ51321, highly similar to Leucine carboxyl methyltransferase 2 (EC 2.1.1.-) 
Gene Name
 LCMT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42DNNTEDLKVTITKAGacetylation[1, 2]
42DNNTEDLKVTITKAGubiquitination[2, 3, 4]
47DLKVTITKAGRKDDSubiquitination[4]
51TITKAGRKDDSTLCCubiquitination[2, 4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 265 AA 
Protein Sequence
MTRLSESRVL VLGGRLSPVS PALGVLQLHF FKSEDNNTED LKVTITKAGR KDDSTLCCWR 60
HSTTEVSCQN QEYLFVYGGR SVVEPVLSDW HFLHVGTMAW VRIPVEGEVP EARHSHSACT 120
WQGGALIAGG LGASEEPLNS VLFLRPISCG FLWESVDIQP PITPRYSHTA HVLNGKLLLV 180
GGIWIHSSSF PGVTVINLTT GLSSEYQIDT TYVPWPLMLH NHTSILLPEE QQLLLLGGGG 240
NCFSFGTYFN PHTVTLDLSS LSAGQ 265 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 
Interpro
 IPR015915; Kelch-typ_b-propeller.
 IPR021121; LCM_MeTrfase_euk. 
Pfam
  
SMART
  
PROSITE
  
PRINTS