CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001405
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyridoxine-5'-phosphate oxidase 
Protein Synonyms/Alias
 Pyridoxamine-phosphate oxidase 
Gene Name
 Pnpo 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
100SARMLLLKGFGKDGFacetylation[1]
104LLLKGFGKDGFRFFTacetylation[1]
187DREYLRKKNEELGQLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). 
Sequence Annotation
 NP_BIND 110 111 FMN (By similarity).
 NP_BIND 174 175 FMN (By similarity).
 REGION 225 227 Substrate binding (By similarity).
 BINDING 95 95 FMN (By similarity).
 BINDING 98 98 FMN; via amide nitrogen (By similarity).
 BINDING 100 100 Substrate (By similarity).
 BINDING 117 117 FMN (By similarity).
 BINDING 157 157 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).
 BINDING 165 165 Substrate (By similarity).
 MOD_RES 165 165 Phosphoserine (By similarity).
 MOD_RES 241 241 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Flavoprotein; FMN; Oxidoreductase; Phosphoprotein; Pyridoxal phosphate; Pyridoxine biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MTCGLLSVTV TFRRPAKWPG YFRHLCCRGA VMDLGPMRKS YRGDREAFEE AHLTSLDPMK 60
QFASWFEEAV QCPDIGEANA MCLATCTRDG KPSARMLLLK GFGKDGFRFF TNYESRKGKE 120
LDSNPFASLV FYWEPLNRQV RVEGPVKKLP EKEAENYFHS RPKSSQIGAV VSRQSSVIPD 180
REYLRKKNEE LGQLYREQEV PKPEYWGGYI LYPQVMEFWQ GQTNRLHDRI VFRRGLATGD 240
SPLGPMTHHG EEDWVYERLA P 261 
Gene Ontology
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0004733; F:pyridoxamine-phosphate oxidase activity; IDA:RGD.
 GO:0008615; P:pyridoxine biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR000659; Pyridox_Oxase.
 IPR019740; Pyridox_Oxase_CS.
 IPR011576; Pyridox_Oxase_FMN-bd.
 IPR019576; Pyridoxamine_oxidase_dimer_C.
 IPR012349; Split_barrel_FMN-bd. 
Pfam
 PF10590; PNPOx_C
 PF01243; Pyridox_oxidase 
SMART
  
PROSITE
 PS01064; PYRIDOX_OXIDASE 
PRINTS