CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038857
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inositol 1,4,5-trisphosphate receptor type 1 
Protein Synonyms/Alias
  
Gene Name
 Itpr1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
84FMKWSDNKDDILKGGacetylation[1]
278KIGTSPLKEDKEAFAubiquitination[2]
313VLGSIAGKLEKGTITacetylation[1]
316SIAGKLEKGTITQNEacetylation[1]
371MREQNILKQIFKLLQacetylation[1]
430KNQEYIAKQFGFMQKacetylation[1]
825DIMVMDTKLKIIEILacetylation[1]
970VDNYKQIKQDLDQLRacetylation[1]
1939KELVEVIKKAYMQGEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2563 AA 
Protein Sequence
MRVTLDEAGN EGSWFYIQPF YKLRSIGDSV VIGDKVVLNP VNAGQPLHAS SHQLVDNPGC 60
NEVNSVNCNT SWKIVLFMKW SDNKDDILKG GDVVRLFHAE QEKFLTCDEH RKKQHVFLRT 120
TGRQSATSAT SSKALWEVEV VQHDPCRGGA GYWNSLFRFK HLATGHYLAA EVDPDFEEEC 180
LEFQPSVDPD QDASRSRLRN AQEKMVYSLV SVPEGNDISS IFELDPTTLR GGDSLVPRNS 240
YVRLRHLCTN TWVHSTNIPI DKEEEKPVML KIGTSPLKED KEAFAIVPVS PAEVRDLDFA 300
NDASKVLGSI AGKLEKGTIT QNERRSVTKL LEDLVYFVTG GTNSGQDVLE VVFSKPNRER 360
QKLMREQNIL KQIFKLLQAP FTDCGDGPML RLEELGDQRH APFRHICRLC YRVLRHSQQD 420
YRKNQEYIAK QFGFMQKQIG YDVLAEDTIT ALLHNNRKLL EKHITAAEID TFVSLVRKNR 480
EPRFLDYLSD LCVSMNKSIP VTQELICKAV LNPTNADILI ETKLVLSRFE FEGVSTGENA 540
LEAGEDEEEV WLFWRDSNKE IRSKSVRELA QDAKEGQKED RDVLSYYRYQ LNLFARMCLD 600
RQYLAINEIS GQLDVDLILR CMSDENLPYD LRASFCRLML HMHVDRDPQE QVTPVKYARL 660
WSEIPSEIAI DDYDSSGASK DEIKERFAQT MEFVEEYLRD VVCQRFPFSD KEKNKLTFEV 720
VNLARNLIYF GFYNFSDLLR LTKILLAILD CVHVTTIFPI SKMTKGEENK GSNVMRSIHG 780
VGELMTQVVL RGGGFLPMTP MAAAPEGNVK QAEPEKEDIM VMDTKLKIIE ILQFILNVRL 840
DYRISCLLCI FKREFDESNS QSSETSSGNS SQEGPSNVPG ALDFEHIEEQ AEGIFGGSEE 900
NTPLDLDDHG GRTFLRVLLH LTMHDYPPLV SGALQLLFRH FSQRQEVLQA FKQVQLLVTS 960
QDVDNYKQIK QDLDQLRSIV EKSELWVYKG QGPDEPMDGA SGENEHKKTE EGTSKPLKHE 1020
STSSYNYRVV KEILIRLSKL CVQESASVRK SRKQQQRLLR NMGAHAVVLE LLQIPYEKAE 1080
DTKMQEIMRL AHEFLQNFCA GNQQNQALLH KHINLFLNPG ILEAVTMQHI FMNNFQLCSE 1140
INERVVQHFV HCIETHGRNV QYIKFLQTIV KAEGKFIKKC QDMVMAELVN SGEDVLVFYN 1200
DRASFQTLIQ MMRSERDRMD ENSPLMYHIH LVELLAVCTE GKNVYTEIKC NSLLPLDDIV 1260
RVVTHEDCIP EVKIAYINFL NHCYVDTEVE MKEIYTSNHM WKLFENFLVD ICRACNNTSD 1320
RKHADSVLEK YVTEIVMSIV TTFFSSPFSD QSTTLQTRQP VFVQLLQGVF RVYHCNWLMP 1380
SQKASVESCI RVLSDVAKSR AIAIPVDLDS QVNNLFLKSH NIVQKTAMNW RLSARNAARR 1440
DSVLAASRDY RNIIERLQDI VSALEDRLRP LVQAELSVLV DVLHRPELLF PENTDARRKC 1500
ESGGFICKLI KHTKQLLEEN EEKLCIKVLQ TLREMMTKDR GYGEKGEALR QILVNRYYGN 1560
IRPSGRRESL TSFGNGPLSP GGPSKPGGGG GGPGSGSTSR GEMSLAEVQC HLDKEGASNL 1620
VIDLIMNASS DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF KVFYDRMKVA 1680
QQEIKATVTV NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ ITEEVRDQLL EASAATRKAF 1740
TTFRREADPD DHYQSGEGTQ ATTDKAKDDL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF 1800
LRCQNNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP 1860
CHENQNCIAT HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE 1920
NAERILYNMR PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY ILAHQLARHN 1980
KELQTMLKPG GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE FLTKESKLRI 2040
YYTTERDEQG SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS SISFNLAVLM 2100
NLLVAFFYPF KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS 2160
VGLQPTLFLL GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLLICAMGLF 2220
VHEFFYSLLL FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI VGYLFFKDDF 2280
ILEVDRLPNE TAGPETGESL ANDFLYSDVC RVETGENCTS PAPKEELLPV EETEQDKEHT 2340
CETLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG 2400
VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL 2460
VKVKDSTEYT GPESYVAEMI RERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK 2520
LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA 2563 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
 GO:0048016; P:inositol phosphate-mediated signaling; IEA:GOC. 
Interpro
 IPR000699; Ca-rel_channel.
 IPR014821; Ins145_P3_rcpt.
 IPR000493; InsP3_rcpt-bd.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR015925; Ryanodine_recept-rel. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF01365; RYDR_ITPR 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS
 PR00779; INSP3RECEPTR.