CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037111
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA repair protein-complementing XP-C cells 
Protein Synonyms/Alias
  
Gene Name
 XPC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
155SRSLLPVKPVEIEIEacetylation[1, 2]
155SRSLLPVKPVEIEIEubiquitination[3, 4, 5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 168 AA 
Protein Sequence
MARKRAAGGE PRGRELRSQK SKAKSKARHA FEDEKPPKKS LLSKVSQGKR KRGCSHPGGS 60
ADGPAKKKVA KVTVKSENLK VIKDEALSDG DDLRDFPSDL KKAHHLKRGA TMNEDSNEEE 120
EESENDWEEV EELSEPVLGD VRESTAFSRS LLPVKPVEIE IETPEQAK 168 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro. 
Interpro
 IPR004583; DNA_repair_Rad4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS