| Tag | Content |
|---|
| CPLM ID | CPLM-017649 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polyhomeotic-like protein 3 |
Protein Synonyms/Alias | Early development regulatory protein 3; Homolog of polyhomeotic 3; hPH3 |
Gene Name | PHC3 |
Gene Synonyms/Alias | EDR3; PH3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 234 | NLTLRSQKLGVLSSS | ubiquitination | [1] | | 281 | PSPESNKKGESPSLE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Sequence Annotation | DOMAIN 919 983 SAM.
ZN_FING 776 810 FCS-type.
MOTIF 691 720 HD1.
MOD_RES 263 263 Phosphoserine.
MOD_RES 272 272 Phosphoserine.
MOD_RES 315 315 Phosphoserine.
MOD_RES 609 609 Phosphothreonine.
MOD_RES 616 616 Phosphoserine.
MOD_RES 761 761 Phosphoserine.
MOD_RES 762 762 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 983 AA |
Protein Sequence | MAEAEFKDHS TAMDTEPNPG TSSVSTTTSS TTTTTITTSS SRMQQPQISV YSGSDRHAVQ 60
VIQQALHRPP SSAAQYLQQM YAAQQQHLML HTAALQQQHL SSSQLQSLAA VQASLSSGRP 120
STSPTGSVTQ QSSMSQTSIN LSTSPTPAQL ISRSQASSST SGSITQQTML LGSTSPTLTA 180
SQAQMYLRAQ MLIFTPATTV AAVQSDIPVV SSSSSSSCQS AATQVQNLTL RSQKLGVLSS 240
SQNGPPKSTS QTQSLTICHN KTTVTSSKIS QRDPSPESNK KGESPSLESR STAVTRTSSI 300
HQLIAPASYS PIQPHSLIKH QQIPLHSPPS KVSHHQLILQ QQQQQIQPIT LQNSTQDPPP 360
SQHCIPLQNH GLPPAPSNAQ SQHCSPIQSH PSPLTVSPNQ SQSAQQSVVV SPPPPHSPSQ 420
SPTIIIHPQA LIQPHPLVSS ALQPGPNLQQ STANQVQATA QLNLPSHLPL PASPVVHIGP 480
VQQSALVSPG QQIVSPSHQQ YSSLQSSPIP IASPPQMSTS PPAQIPPLPL QSMQSLQVQP 540
EILSQGQVLV QNALVSEEEL PAAEALVQLP FQTLPPPQTV AVNLQVQPPA PVDPPVVYQV 600
EDVCEEEMPE ESDECVRMDR TPPPPTLSPA AITVGRGEDL TSEHPLLEQV ELPAVASVSA 660
SVIKSPSDPS HVSVPPPPLL LPAATTRSNS TSMHSSIPSI ENKPPQAIVK PQILTHVIEG 720
FVIQEGLEPF PVSRSSLLIE QPVKKRPLLD NQVINSVCVQ PELQNNTKHA DNSSDTEMED 780
MIAEETLEEM DSELLKCEFC GKMGYANEFL RSKRFCTMSC AKRYNVSCSK KFALSRWNRK 840
PDNQSLGHRG RRPSGPDGAA REHILRQLPI TYPSAEEDLA SHEDSVPSAM TTRLRRQSER 900
ERERELRDVR IRKMPENSDL LPVAQTEPSI WTVDDVWAFI HSLPGCQDIA DEFRAQEIDG 960
QALLLLKEDH LMSAMNIKLG PALKICARIN SLKES 995 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |