CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oral-facial-digital syndrome 1 protein 
Protein Synonyms/Alias
 Protein 71-7A 
Gene Name
 OFD1 
Gene Synonyms/Alias
 CXorf5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
175NRDSLAEKLQLIDDQubiquitination[1]
444PELAVFQKELRKAEKubiquitination[1]
592LEFVANTKARVKELQubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity). 
Sequence Annotation
 DOMAIN 70 102 LisH.
 REGION 609 665 Mediates homooligomerization.
 REGION 615 1012 Mediates the interaction with SDCCAG8.
 MOD_RES 663 663 Phosphoserine.
 MOD_RES 669 669 Phosphoserine.
 MOD_RES 686 686 Phosphoserine.  
Keyword
 Alternative splicing; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Joubert syndrome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1012 AA 
Protein Sequence
MMAQSNMFTV ADVLSQDELR KKLYQTFKDR GILDTLKTQL RNQLIHELMH PVLSGELQPR 60
SISVEGSSLL IGASNSLVAD HLQRCGYEYS LSVFFPESGL AKEKVFTMQD LLQLIKINPT 120
SSLYKSLVSG SDKENQKGFL MHFLKELAEY HQAKESCNME TQTSSTFNRD SLAEKLQLID 180
DQFADAYPQR IKFESLEIKL NEYKREIEEQ LRAEMCQKLK FFKDTEIAKI KMEAKKKYEK 240
ELTMFQNDFE KACQAKSEAL VLREKSTLER IHKHQEIETK EIYAQRQLLL KDMDLLRGRE 300
AELKQRVEAF ELYQLELKDD YIIRTNRLIE DERKNKEKAV HLQEELIAIN SKKEELNQSV 360
NRVKELELEL ESVKAQSLAI TKQNHMLNEK VKEMSDYSLL KEEKLELLAQ NKLLKQQLEE 420
SRNENLRLLN RLAQPAPELA VFQKELRKAE KAIVVEHEEF ESCRQALHKQ LQDEIEHSAQ 480
LKAQILGYKA SVKSLTTQVA DLKLQLKQTQ TALENEVYCN PKQSVIDRSV NGLINGNVVP 540
CNGEISGDFL NNPFKQENVL ARMVASRITN YPTAWVEGSS PDSDLEFVAN TKARVKELQQ 600
EAERLEKAFR SYHRRVIKNS AKSPLAAKSP PSLHLLEAFK NITSSSPERH IFGEDRVVSE 660
QPQVGTLEER NDVVEALTGS AASRLRGGTS SRRLSSTPLP KAKRSLESEM YLEGLGRSHI 720
ASPSPCPDRM PLPSPTESRH SLSIPPVSSP PEQKVGLYRR QTELQDKSEF SDVDKLAFKD 780
NEEFESSFES AGNMPRQLEM GGLSPAGDMS HVDAAAAAVP LSYQHPSVDQ KQIEEQKEEE 840
KIREQQVKER RQREERRQSN LQEVLERERR ELEKLYQERK MIEESLKIKI KKELEMENEL 900
EMSNQEIKDK SAHSENPLEK YMKIIQQEQD QESADKSSKK MVQEGSLVDT LQSSDKVESL 960
TGFSHEELDD SW 972 
Gene Ontology
 GO:0005814; C:centriole; IDA:UniProtKB.
 GO:0005929; C:cilium; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005932; C:microtubule basal body; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043014; F:alpha-tubulin binding; ISS:UniProtKB.
 GO:0043015; F:gamma-tubulin binding; ISS:UniProtKB.
 GO:0035083; P:cilium axoneme assembly; IEA:Compara.
 GO:0060271; P:cilium morphogenesis; ISS:UniProtKB.
 GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome. 
Interpro
 IPR006594; LisH_dimerisation. 
Pfam
  
SMART
 SM00667; LisH 
PROSITE
 PS50896; LISH 
PRINTS