CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031330
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor AP-2 gamma 
Protein Synonyms/Alias
 cDNA FLJ50899, highly similar to Transcription factor AP-2 gamma 
Gene Name
 TFAP2C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42PLNLPCQKELVGAVMubiquitination[1]
70SLLSSTSKYKVTVAEubiquitination[1]
72LSSTSKYKVTVAEVQubiquitination[2, 3]
112GGRSLREKLDKIGLNubiquitination[2]
115SLREKLDKIGLNLPAubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 281 AA 
Protein Sequence
MPHQMDEVQN VDDQHLLLHD QTVIRKGPIS MTKNPLNLPC QKELVGAVMN PTEVFCSVPG 60
RLSLLSSTSK YKVTVAEVQR RLSPPECLNA SLLGGVLRRA KSKNGGRSLR EKLDKIGLNL 120
PAGRRKAAHV TLLTSLVEGE AVHLARDFAY VCEAEFPSKP VAEYLTRPHL GGRNEMAARK 180
NMLLAAQQLC KEFTELLSQD RTPHGTSRLA PVLETNIQNC LSHFSLITHG FGSQAICAAV 240
SALQNYIKEA LIVIDKSYMN PGDQSPADSN KTLEKMEKHR K 281 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0060598; P:dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IEA:Compara.
 GO:0021877; P:forebrain neuron fate commitment; IEA:Compara.
 GO:0030718; P:germ-line stem cell maintenance; IEA:Compara.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0003334; P:keratinocyte development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045682; P:regulation of epidermis development; IEA:Compara.
 GO:0048733; P:sebaceous gland development; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0001829; P:trophectodermal cell differentiation; IEA:Compara. 
Interpro
 IPR004979; TF_AP2.
 IPR013854; TF_AP2_C. 
Pfam
 PF03299; TF_AP-2 
SMART
  
PROSITE
  
PRINTS
 PR01748; AP2TNSCPFCT.