CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026859
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 
Protein Synonyms/Alias
 Caseinolytic peptidase X (E.coli) 
Gene Name
 Clpx 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127VSSTRFVKCEKCHHFacetylation[1]
462THQDIEEKDRLLRHVacetylation[1, 2]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 620 AA 
Protein Sequence
MSSCGACTCG AAAARLLTTS LTSAQRGISC GRIHVPVLGR LGTTLDAQAL RRAPLRTFSE 60
TPAYFASKDG ANKDGSGDGN KKSVTEGSSK KSGSGNSGKG GNQLRCPKCG DLCTHVETFV 120
SSTRFVKCEK CHHFFVVLSE ADSKKSIIKE PESAAEAVKL AFQQKPPPPP KKIYNYLDKY 180
VVGQSFAKKV LSVAVYNHYK RIYNNIPANL RQQAEAEKQT SLTPRELLQI AGISPHGNAL 240
GASMQQQVNQ QMPQEKRGGE VLDSSQDDIK LEKSNILLLG PTGSGKTLLA QTLAKCLDVP 300
FAICDCTTLT QAGYVGEDIE SVIAKLLQDA NYNVEKAQQG IVFLDEVDKI GSVPGIHQLR 360
DVGGEGVQQG LLKLLEGTIV NVPEKNSRKL RGETVQVDTT NVLFVASGAF NGLDRIISRR 420
KNEKYLGFGT PSNLGKGRRA AAAADLANRS GESNTHQDIE EKDRLLRHVE ARDLIEFGMI 480
PEFVGRLPVV VPLHSLDEKT LVQILTEPRN AVIPQYQALF SMDKCELNVT EDALKAIARL 540
ALERKTGARG LRSIMEKLLL EPMFEVPNSD IVCVEVDKEV VEGKKEPGYI RAPSKESSEE 600
EYDSGVEEDG WPRQADAANS 620 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0016887; F:ATPase activity; IDA:MGI.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013093; ATPase_AAA-2.
 IPR019489; Clp_ATPase_C.
 IPR004487; Clp_protease_ATP-bd_su_ClpX.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07724; AAA_2
 PF10431; ClpB_D2-small 
SMART
 SM00382; AAA
 SM01086; ClpB_D2-small 
PROSITE
  
PRINTS