CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tryptophan--tRNA ligase 
Protein Synonyms/Alias
 Tryptophanyl-tRNA synthetase; TrpRS 
Gene Name
 trpS 
Gene Synonyms/Alias
 STM3481 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
307AFLQKVMKDGAEKASacetylation[1]
312VMKDGAEKASARAAEacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 MOTIF 12 20 "HIGH" region.
 MOTIF 195 199 "KMSKS" region.
 BINDING 198 198 ATP (By similarity).  
Keyword
 3D-structure; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 334 AA 
Protein Sequence
MTKPIVFSGA QPSGELTIGN YMGALRQWVN MQDDYHCIYC IVDQHAITVR QDAQQLRKAT 60
LDTLALYLAC GIDPEKSTIF VQSHVPEHAQ LGWALNCYTY FGELSRMTQF KDKSARYAEN 120
INAGLFDYPV LMAADILLYQ TNLVPVGEDQ KQHLELSRDI AQRFNGLYGD IFKVPEPFIP 180
KSGARVMSLL EPTKKMSKSD DNRNNVIGLL EDPKSVVKKI KRAVTDSDEP PVVRYDVKEK 240
AGVSNLLDIL SAVTGQSIPE LEKQFEGKMY GHLKGEVAEA VSGMLSELQE RYHRFRNDEA 300
FLQKVMKDGA EKASARAAET LKAVYEAIGF VAKP 334 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004830; F:tryptophan-tRNA ligase activity; IEA:HAMAP.
 GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002305; aa-tRNA-synth_Ic.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR002306; Trp-tRNA-ligase.
 IPR024109; Trp-tRNA-ligase_bac-type. 
Pfam
 PF00579; tRNA-synt_1b 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR01039; TRNASYNTHTRP.