UniProt Accession

 GPSM2_HUMAN; P81274; Q5T1N8; Q6IBL7; Q8N0Z5 

Genbank Protein ID

 U54999; AB445462; AL449266; CH471122; BC027732; AY136740; CR456786 

Genbank Nucleotide ID

 AAB40385.1; BAH84760.1; CAI14361.1; EAW56340.1; AAH27732.1; AAN01266.1; CAG33067.1 

Protein Name

 G-protein-signaling modulator 2 

Protein Synonyms/Alias

 Mosaic protein LGN 

Gene Name

 GPSM2 

Gene Synonyms/Alias

 LGN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	GDQLGEAKASGNLGN	ubiquitination	[1, 2, 3]
113	GNLGNTLKVLGNFDE	ubiquitination	[3]
233	EQRLLIAKEFGDKAA	ubiquitination	[3]
238	IAKEFGDKAAERRAY	ubiquitination	[3]
481	RIPNSQRKISADTIG	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. 

Sequence Annotation

 REPEAT 24 57 TPR 1.
 REPEAT 62 95 TPR 2.
 REPEAT 102 135 TPR 3.
 REPEAT 142 184 TPR 4.
 REPEAT 202 235 TPR 5.
 REPEAT 242 275 TPR 6.
 REPEAT 282 315 TPR 7.
 REPEAT 322 355 TPR 8.
 DOMAIN 489 511 GoLoco 1.
 DOMAIN 544 566 GoLoco 2.
 DOMAIN 594 616 GoLoco 3.
 DOMAIN 628 650 GoLoco 4.
 MOD_RES 132 132 Phosphoserine; by PKG (Potential).
 MOD_RES 352 352 Phosphoserine; by PKG (Potential).
 MOD_RES 408 408 Phosphoserine.
 MOD_RES 483 483 Phosphoserine.
 MOD_RES 486 486 Phosphothreonine.
 MOD_RES 501 501 Phosphoserine; by PKC (Potential).
 MOD_RES 541 541 Phosphoserine.
 MOD_RES 565 565 Phosphoserine.
 MOD_RES 607 607 Phosphoserine; by PKG (Potential).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Deafness; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 684 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro.
 GO:0000132; P:establishment of mitotic spindle orientation; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0060487; P:lung epithelial cell differentiation; IEA:Compara.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro. 

Interpro

 IPR024807; G_prot_signal_mod_2.
 IPR003109; GoLoco_motif.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF02188; GoLoco
 PF00515; TPR_1
 PF13176; TPR_7 

SMART

 SM00390; GoLoco
 SM00028; TPR 

PROSITE

 PS50877; GOLOCO
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS