CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017310
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat LGI family member 2 
Protein Synonyms/Alias
 LGI1-like protein 2; Leucine-rich glioma-inactivated protein 2 
Gene Name
 LGI2 
Gene Synonyms/Alias
 KIAA1916; LGIL2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174NKFECDCKAKWLYLWacetylation[1]
176FECDCKAKWLYLWLKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 DOMAIN 29 65 LRRNT.
 REPEAT 86 107 LRR 1.
 REPEAT 110 131 LRR 2.
 REPEAT 134 155 LRR 3.
 DOMAIN 167 217 LRRCT.
 REPEAT 218 261 EAR 1.
 REPEAT 264 307 EAR 2.
 REPEAT 310 358 EAR 3.
 REPEAT 359 403 EAR 4.
 REPEAT 406 450 EAR 5.
 REPEAT 451 494 EAR 6.
 REPEAT 497 540 EAR 7.
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 402 402 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 545 AA 
Protein Sequence
MALRRGGCGA LGLLLLLLGA ACLIPRSAQV RRLARCPATC SCTKESIICV GSSWVPRIVP 60
GDISSLSLVN GTFSEIKDRM FSHLPSLQLL LLNSNSFTII RDDAFAGLFH LEYLFIEGNK 120
IETISRNAFR GLRDLTHLSL ANNHIKALPR DVFSDLDSLI ELDLRGNKFE CDCKAKWLYL 180
WLKMTNSTVS DVLCIGPPEY QEKKLNDVTS FDYECTTTDF VVHQTLPYQS VSVDTFNSKN 240
DVYVAIAQPS MENCMVLEWD HIEMNFRSYD NITGQSIVGC KAILIDDQVF VVVAQLFGGS 300
HIYKYDESWT KFVKFQDIEV SRISKPNDIE LFQIDDETFF VIADSSKAGL STVYKWNSKG 360
FYSYQSLHEW FRDTDAEFVD IDGKSHLILS SRSQVPIILQ WNKSSKKFVP HGDIPNMEDV 420
LAVKSFRMQN TLYLSLTRFI GDSRVMRWNS KQFVEIQALP SRGAMTLQPF SFKDNHYLAL 480
GSDYTFSQIY QWDKEKQLFK KFKEIYVQAP RSFTAVSTDR RDFFFASSFK GKTKIFEHII 540
VDLSL 545 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR009039; EAR.
 IPR005492; EPTP.
 IPR003591; Leu-rich_rpt_typical-subtyp. 
Pfam
 PF03736; EPTP 
SMART
 SM00369; LRR_TYP
 SM00082; LRRCT 
PROSITE
 PS50912; EAR 
PRINTS